OpenAccess: Closed

This work is not Open Acccess. We may still have a PDF, if this is the case there will be a green box below.

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

Christine E. Canman,Dae–Sik Lim,Karlene A. Cimprich,Yoichi Taya,Katsuyuki Tamai,Kazuyasu Sakaguchi,Ettore Appella,Michael B. Kastan,Janet D. Siliciano

Phosphorylation

DNA-PKcs

Ionizing radiation

1998

The p53 tumor suppressor protein is activated and phosphorylated on serine-15 in response to various DNA damaging agents. The gene product mutated in ataxia telangiectasia, ATM, acts upstream of p53 in a signal transduction pathway initiated by ionizing radiation. Immunoprecipitated ATM had intrinsic protein kinase activity and phosphorylated p53 on serine-15 in a manganese-dependent manner. Ionizing radiation, but not ultraviolet radiation, rapidly enhanced this p53-directed kinase activity of endogenous ATM. These observations, along with the fact that phosphorylation of p53 on serine-15 in response to ionizing radiation is reduced in ataxia telangiectasia cells, suggest that ATM is a protein kinase that phosphorylates p53 in vivo.

Cite this:

Generate Citation

“Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53” is a paper by Christine E. Canman Dae–Sik Lim Karlene A. Cimprich Yoichi Taya Katsuyuki Tamai Kazuyasu Sakaguchi Ettore Appella Michael B. Kastan Janet D. Siliciano published in 1998. It has an Open Access status of “closed”. You can read and download a PDF Full Text of this paper here.