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DOI: 10.1038/s41467-019-13929-1
¤ OpenAccess: Gold
This work has “Gold” OA status. This means it is published in an Open Access journal that is indexed by the DOAJ.

Combined burden and functional impact tests for cancer driver discovery using DriverPower

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Wheeler,Guanming Wu,Jun Yu,Jing Zhang,Xuanping Zhang,Yan Zhang,Zhongming Zhao,Lihua Zou,Christian von Mering,Steven Gallinger,Lincoln D. Stein,Lauri A. Aaltonen,John R. McPherson,Gad Getz,Hiroyuki Aburatani,David J. Adams,Marcin Imieliński,Keun Soo Ahn,Sung-Min Ahn,Alvin Wei Tian Ng,Yuan Ji,Kadir C. Akdemir,Hikmat Al‐Ahmadie,Sultan T. Al‐Sedairy,Fátima Al‐Shahrour,Malik Alawi,Monique Albert,Kenneth Aldape,Florian Markowetz,Adrian Ally,Kathryn Alsop,Eva G. Álvarez,Fernanda Amary,Samirkumar B. Amin,Brice Aminou,Ole Ammerpohl,Matthew Anderson,Yeng Ang,Davide Antonello,Pavana Anur,Samuel Aparicio,Elizabeth L. Appelbaum,Yasuhito Arai,Axel Aretz,Koji Arihiro,Shun‐ichi Ariizumi,Joshua Armenia,Laurent Arnould,L. Sylvia,Yassen Assenov,Gurnit Atwal,Sietse Aukema,J. Todd Auman,Rameen Beroukhim,Chad J. Creighton,Marta Aymerich,Gary D. Bader,Adrian Baez‐Ortega,Matthew H. Bailey,Peter J. Bailey,Miruna Balasundaram,Saianand Balu,Pratiti Bandopadhayay,Rosamonde E. Banks,David C. Wedge,Andrew P. Barbour,Jonathan Barenboim,Jill S. Barnholtz‐Sloan,Hugh Barr,Elisabet Barrera,John G. Bartlett,Javier Bartolomé,Claudio Bassi,Oliver F. Bathe,Daniel Baumhoer,Prashant Bavi,Lars Feuerbach,Wojciech Bażant,Duncan Beardsmore,Timothy A. Beck,Sam Behjati,Andreas Behren,Beifang Niu,Cindy Bell,Sergi Beltrán,Christopher C. Benz,Andrew Berchuck,Anke Bergmann,Erik N. Bergstrom,Benjamin P. Berman,Daniel M. Berney,Stephan H. Bernhart,Rameen Beroukhim,Mario Berríos,Samantha Bersani,Johanna Bertl,Miguel Betancourt,Vinayak Bhandari,Shriram G. Bhosle,Andrew V. Biankin,Matthias Bieg,Darell D. Bigner,Hans Binder,Ewan Birney,Michael Birrer,Nidhan K. Biswas,Bodil Bjerkehagen,Tom Bodenheimer,Lori Boice,Giada Bonizzato,Johann S. de Bono,Arnoud Boot,Moiz S. Bootwalla,Åke Borg,Arndt Borkhardt,Keith A. Boroevich,Ivan Borozan,Christoph W. Borst,Marcus Bosenberg,Mattia Bosio,Jacqueline Boultwood,Guillaume Bourque,Paul C. Boutros,G. Steven Bova,David Bowen,Reanne Bowlby,David D.L. 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Chantrill,Aurélien Chateigner,Nilanjan Chatterjee,Kazuaki Chayama,Hsiao‐Wei Chen,Jieming Chen,Ken Chen,Yiwen Chen,Zhaohong Chen,Andrew D. Cherniack,Jeremy Chien,Yoke-Eng Chiew,Suet‐Feung Chin,Juok Cho,Sunghoon Cho,Jung Kyoon Choi,Wan Choi,Christine Chomienne,Zechen Chong,Su Pin Choo,Angela Chou,Angelika N. Christ,Elizabeth L. Christie,Eric Chuah,Carrie Cibulskis,Kristian Cibulskis,Sara Cingarlini,Peter Clapham,Alexander Claviez,Sean P. Cleary,Nicole Cloonan,Marek Cmero,Colin C. Collins,Ashton A. Connor,Susanna L. Cooke,Christopher S. Cooper,Leslie Cope,Vincenzo Corbo,Matthew G. Cordes,Stephen Cordner,Isidro Cortés‐Ciriano,Kyle R. Covington,Prue A. Cowin,Brian Craft,David Craft,Chad J. Creighton,Yupeng Cun,Erin Curley,Ioana Cutcutache,Karolina Czajka,Bogdan Czerniak,Rebecca A. Dagg,Ludmila Danilova,Maria Vittoria Davì,Natalie R. Davidson,Helen Davies,Ian J. Davis,Brandi N. Davis‐Dusenbery,Kevin J. Dawson,Francisco M. De La Vega,Ricardo De Paoli‐Iseppi,Timothy Defreitas,Angelo Paolo Dei Tos,Olivier Delaneau,John A. Demchok,Jonas Demeulemeester,German Demidov,Deniz Demircioğlu,Nening M. Dennis,Robert E. Denroche,Stefan C. Dentro,Nikita Desai,Vikram Deshpande,Amit G. Deshwar,Christine Desmedt,Jordi Deu-Pons,Noreen Dhalla,Neesha C. Dhani,Priyanka Dhingra,Rajiv Dhir,Anthony DiBiase,Klev Diamanti,Li Ding,Shuai Ding,Huy Q. Dinh,Luc Dirix,HarshaVardhan Doddapaneni,Nilgun Donmez,Michelle T. Dow,Ronny Drapkin,Oliver Drechsel,Ruben M. Drews,Serge Serge,Tim Dudderidge,Elisabet Barrera,Andrew Dunford,Michael Dunn,Lewis Jonathan Dursi,Fraser R. Duthie,Ken Dutton‐Regester,Jenna Eagles,Douglas F. Easton,Stuart Edmonds,Paul A. Edwards,Sandra E. Edwards,Rosalind Eeles,Anna Ehinger,Juergen Eils,Roland Eils,Adel K. El‐Naggar,Matthew Eldridge,Kyle Ellrott,Serap Erkek,Geòrgia Escaramís,Shadrielle M. G. Espiritu,Xavier Estivill,Dariush Etemadmoghadam,Jorunn E. Eyfjord,Lincoln Stein,Daiming Fan,Yu Fan,William C. Faquin,Claudiu Farcas,Matteo Fassan,Aquila Fatima,Francesco Favero,Nodirjon Fayzullaev,Ina Felau,Sián Fereday,Martin L. Ferguson,Vincent Ferretti,Lars Feuerbach,Matthew A. Field,J. Lynn Fink,Gaetano Finocchiaro,Cyril Fisher,Matthew W. Fittall,Anna Fitzgerald,Rebecca Fitzgerald,Adrienne M. Flanagan,Neil Fleshner,Paul Flicek,John A. Foekens,Kwun M. Fong,Nuno A. Fonseca,Christopher S. Foster,Natalie S. Fox,Michael Fraser,Scott Frazer,Milana Frenkel‐Morgenstern,William A. Friedman,Gordon Saksena,Catrina C. Fronick,Akihiro Fujimoto,Masashi Fujita,Masashi Fukayama,Lucinda A. Fulton,Robert S. Fulton,Mayuko Furuta,P. Andrew Futreal,Anja Füllgrabe,Stacey Gabriel,Steven Gallinger,Carlo Gambacorti‐Passerini,Jianjiong Gao,Shengjie Gao,Levi A. Garraway,Øystein Garred,Erik Garrison,Dale W. Garsed,Nils Gehlenborg,Josep L. L. Gelpi,Joshy George,Daniela S. Gerhard,Clarissa Gerhäuser,Jeffrey E. Gershenwald,Mark Gerstein,Moritz Gerstung,Gad Getz,Mohammed Ghori,Ronald Ghossein,Nasra H. Giama,Richard A. Gibbs,Bob Gibson,Anthony J. Gill,Pelvender Gill,Dilip D. Giri,Dominik Glodzik,Vincent J. Gnanapragasam,Maria Elisabeth Goebler,Mary J. Goldman,Carmen Gómez,Gad Getz,Abel Pérez‐González,Dmitry A. Gordenin,James Gossage,Kunihito Gotoh,Ramaswamy Govindan,Dorthe Grabau,Janet Graham,Robert C. Grant,Anthony R. Green,Eric Green,Liliana Greger,Nicola Grehan,Sonia Grimaldi,Sean M. Grimmond,Robert L. Grossman,Adam Grundhoff,Gunes Gundem,Qianyun Guo,Manaswi Gupta,Shailja Gupta,Marta Gut,Marta Gut,Jonathan Göke,Gavin Ha,Andrea Haake,David Haan,Siegfried Haas,Kerstin Haase,James E. Haber,Nina Habermann,Faraz Hach,Syed Haider,Natsuko Hama,Freddie C. Hamdy,Anne Hamilton,Mark P. Hamilton,Leng Han,George B. Hanna,Martin Hansmann,Nicholas J. Haradhvala,Olivier Harismendy,Ivon Harliwong,Mark A. Rubin,Eoghan Harrington,Takanori Hasegawa,David Haussler,Steve Hawkins,Shinya Hayami,Shuto Hayashi,D. Neil Hayes,Stephen J. Hayes,Nicholas K. Hayward,Steven Hazell,Yuan He,Allison P. Heath,Simon Heath,David Hedley,Apurva M. Hegde,David I. Heiman,Michael C. Heinold,Zachary Heins,Lawrence E. Heisler,Eva Hellström‐Lindberg,Mohamed Helmy,Seong Heo,Austin J. Hepperla,José María Heredia‐Genestar,Carl Herrmann,Peter Hersey,Julian M. Hess,Hólmfríður Hilmarsdóttir,Jonathan Hinton,Satoshi Hirano,Nobuyoshi Hiraoka,Katherine A. Hoadley,Asger Hobolth,Ermin Hodzic,Jessica I. Hoell,Steve Hoffmann,Elisabet Barrera,Andrea Holbrook,Aliaksei Z. Holik,Michael A. Hollingsworth,Oliver Holmes,Robert A. Holt,Hong Chen,Eun Pyo Hong,Jongwhi H. Hong,Gerrit K. Hooijer,Henrik Hornshøj,Fumie Hosoda,Yong Hou,Patrick Y. Wen,William Howat,Alan P. Hoyle,Ralph H. Hruban,Jianhong Hu,Taobo Hu,Xing Hua,Kuan-lin Huang,Mei Huang,Mi Huang,Vincent Huang,Yuheng Huang,Wolfgang Huber,Thomas J. Hudson,Michael Hummel,Jillian A. Hung,David G. Huntsman,Ted R. Hupp,Jason T. Huse,Matthew R. Huska,Barbara Hutter,Carolyn M. Hutter,Daniel Hübschmann,Christine A. Iacobuzio-Donahue,Charles D. Imbusch,Marcin Imieliński,Seiya Imoto,William B. Isaacs,Keren Isaev,Shumpei Ishikawa,Murat Iskar,S. M. Ashiqul Islam,Michael Ittmann,Sinisa Ivkovic,Jose M. G. Izarzugaza,Jocelyne Jacquemier,Valerie Jakrot,Nigel B. Jamieson,Gun Ho Jang,Se Jin Jang,Joy C. Jayaseelan,Reyka Jayasinghe,Stuart R. Jefferys,Karine Jegalian,Jennifer L. Jennings,Seung-Hyup Jeon,Lara Jerman,Jian Yuan,Wei Jiao,Peter Johansson,Amber L. Johns,Jeremy Johns,Rory Johnson,Todd A. Johnson,Clemency Jolly,Yann Joly,Jon G. Jónasson,Corbin D. Jones,David R. Jones,David T. Jones,Nic Jones,Steve Jones,Jos Jonkers,Young Seok Ju,Hartmut Juhl,Jongsun Jung,Malene Juul,Randi Istrup Juul,Sissel Juul,Natalie Jäger,Rolf Kabbe,André Kahles,Abdullah Kahraman,Vera B. Kaiser,Hojabr Kakavand,Sangeetha Kalimuthu,Christof von Kalle,Koo Jeong Kang,Katalin Karászi,Beth Y. Karlan,Rosa Karlić,Dennis Karsch,Katayoon Kasaian,Karin S. Kassahn,Hitoshi Katai,Mamoru Kato,Hiroto Katoh,Yoshiiku Kawakami,Jonathan D. Kay,Stephen H. Kazakoff,Marat D. Kazanov,Maria Keays,Electron Kebebew,Richard Kefford,Manolis Kellis,James G. Kench,Catherine J. Kennedy,Jules N. A. Kerssemakers,David Khoo,Vincent Khoo,Narong Khuntikeo,Genta Nagae,Helena Kilpinen,Hark Kyun Kim,Hyung‐Lae Kim,Hyung-Yong Kim,Hyunghwan Kim,Jaegil Kim,Jihoon Kim,Jong K. Kim,Youngwook Kim,Tari A. King,Wolfram Klapper,Kortine Kleinheinz,Leszek J. Klimczak,Stian Knappskog,Michael Kneba,Bartha Maria Knoppers,Youngil Koh,Jan Komorowski,Daisuke Komura,Mitsuhiro Komura,Gu Kong,Marcel Kool,Jan O. Korbel,Viktoriya Korchina,Andrey Korshunov,Michael Koscher,Roelof Koster,Zsofia Kote‐Jarai,Antonios Koures,Milena Kovačević,Bárbara Kremeyer,Helene Kretzmer,Markus Kreuz,Savitri Krishnamurthy,Dieter Kube,Kiran Kumar,Pardeep Kumar,Sushant Kumar,Yogesh Kumar,Ritika Kundra,Kirsten Kübler,Ralf Küppers,Jesper Lagergren,Phillip H. Lai,Peter W. Laird,Sunil R. Lakhani,Christopher M. Lalansingh,Emilie Lalonde,Fabien C. Lamaze,Adam Lambert,Eric S. 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Louis,Laurence Lovat,Yiling Lu,Yong‐Jie Lu,Youyong Lü,Claudio Luchini,Ilinca M. Lungu,Xi Luo,Hayley J. Luxton,Andy G. Lynch,Lisa Lype,Cristina López,Carlos López-Otín,Z. Eric,Yussanne Ma,Gaëtan MacGrogan,Shona MacRae,Geoff Macintyre,Tobias Madsen,Kazuhiro Maejima,Andrea Mafficini,Dennis T. Maglinte,Arindam Maitra,Partha P. Majumder,Luca Malcovati,Salem Malikić,Giuseppe Malleo,Graham J. Mann,Luisa Mantovani‐Löffler,Kathleen Marchal,Giovanni Marchegiani,Elaine R. Mardis,Adam A. Margolin,Maximillian G. Marin,Florian Markowetz,Julia Markowski,Jeffrey S. Marks,Tomàs Marquès‐Bonet,Marco A. Marra,Luke Marsden,John W.M. Martens,Sancha Martin,José I. Martín‐Subero,Iñigo Martincorena,Alexander Martínez-Fundichely,Yosef E. Maruvka,R. Jay Mashl,Charlie E. Massie,Thomas J. Matthew,Lucy Matthews,Erik Mayer,Simon Mayes,M. A. Mayo,Faridah Mbabaali,Karen McCune,Ultan McDermott,Patrick D. McGillivray,Michael D. McLellan,John D. McPherson,John R. McPherson,Treasa A. McPherson,Samuel R. 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Shriver,Shimin Shuai,Gad Getz,Reiner Siebert,Anieta M. Sieuwerts,Steven A. Roberts,Sabina Signoretti,Katarzyna Sikora,Michele Simbolo,Ronald Simon,Janae V. Simons,Jared T. Simpson,Peter T. Simpson,Samuel Singer,Nasa Sinnott-Armstrong,Payal Sipahimalani,Tara Skelly,Marcel Smid,Jaclyn Smith,Karen Smith‐McCune,Nicholas D. Socci,Heidi J. Sofia,Matthew G. Soloway,Lei Song,Anil K. Sood,Sharmila Sothi,Christos Sotiriou,Cameron M. Soulette,Paul N. Span,Paul T. Spellman,Nicola Sperandio,Andrew Spillane,Oliver Spiro,Jonathan Spring,Johan Staaf,Peter F. Stadler,Peter Staib,Stefan G. Stark,Lucy Stebbings,Ólafur Andri Stefánsson,Oliver Stegle,Lincoln D. Stein,Alasdair Stenhouse,Chip Stewart,Stephan Stilgenbauer,Miranda D. Stobbe,Michael R. Stratton,Jonathan R. Stretch,Adam J. Struck,Joshua M. Stuart,Henk G. Stunnenberg,Hong Su,Xiaoping Su,Ren Sun,Stéphanie Sungalee,Hana Sušak,Akihiro Suzuki,Fred C.G.J. 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Genome
Computational biology
Coding (social sciences)
2020
Abstract The discovery of driver mutations is one of the key motivations for cancer genome sequencing. Here , as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium , which aggregated whole genome sequencing data from 2658 cancers across 38 tumour types, we describe DriverPower, a software package that uses mutational burden and functional impact evidence to identify driver mutations in coding and non-coding sites within cancer whole genomes. Using a total of 1373 genomic features derived from public sources, DriverPower’s background mutation model explains up to 93% of the regional variance in the mutation rate across multiple tumour types. By incorporating functional impact scores, we are able to further increase the accuracy of driver discovery. Testing across a collection of 2583 cancer genomes from the PCAWG project, DriverPower identifies 217 coding and 95 non-coding driver candidates. Comparing to six published methods used by the PCAWG Drivers and Functional Interpretation Working Group, DriverPower has the highest F1 score for both coding and non-coding driver discovery. This demonstrates that DriverPower is an effective framework for computational driver discovery.
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    Combined burden and functional impact tests for cancer driver discovery using DriverPower” is a paper by Shimin Shuai John R. McPherson Samirkumar B. Amin Gary D. Bader Pratiti Bandopadhayay Jonathan Barenboim Rameen Beroukhim Johanna Bertl Keith A. Boroevich Søren Brunak Martijn P. Lolkema Youngwook Kim Dimple Chakravarty Calvin Wing Yiu Chan Ken Chen Jung Kyoon Choi Jordi Deu-Pons Priyanka Dhingra Klev Diamanti Lars Feuerbach J. Lynn Fink Nuno A. Fonseca Gordon Saksena Carlo Gambacorti‐Passerini Dale W. Garsed Mark Gerstein Gad Getz Qianyun Guo Marta Gut David Haan Mark P. Hamilton Nicholas J. Haradhvala Mark A. Rubin Mohamed Helmy Carl Herrmann Julian M. Hess Asger Hobolth Ermin Hodzic Hong Chen Henrik Hornshøj Keren Isaev Jose M. G. Izarzugaza Rory Johnson Todd A. Johnson Malene Juul Randi Istrup Juul André Kahles Abdullah Kahraman Manolis Kellis Genta Nagae Jaegil Kim Jong K. Kim Youngwook Kim Jan Komorowski Jan O. Korbel Sushant Kumar Andrés Lanzós Erik G. Larsson Michael S. Lawrence Donghoon Lee Fenglin Liu Shantao Li Xiaotong Li Ziao Lin Eric Minwei Liu Lucas Lochovsky Shaoke Lou Tobias Madsen Kathleen Marchal Iñigo Martincorena Alexander Martínez-Fundichely Yosef E. Maruvka Patrick D. McGillivray William Meyerson Ferran Muiños Loris Mularoni Hidewaki Nakagawa Esther Rheinbay Marta Paczkowska Keunchil Park Kiejung Park Jakob Skou Pedersen Tirso Pons Sergio Pulido-Tamayo Benjamin J. Raphael Jüri Reimand Iker Reyes-Salazar Matthew A. Reyna Esther Rheinbay Mark A. Rubin Carlota Rubio-Pérez S. Cenk Şahinalp Gordon Saksena Leonidas Salichos Chris Sander Steven E. Schumacher Mark Shackleton Ofer Shapira Ciyue Shen Raunak Shrestha Shimin Shuai Gad Getz Steven A. Roberts Nasa Sinnott-Armstrong Lincoln D. Stein Joshua M. Stuart David Tamborero Grace Tiao Tatsuhiko Tsunoda Husen M. Umer Liis Uusküla-Reimand Alfonso Valencia Miguél Vázquez Lieven P. C. Verbeke Claes Wadelius Lina Wadi Jiayin Wang Jonathan Warrell Sebastian M. Waszak Davide Antonello David A. Wheeler Guanming Wu Jun Yu Jing Zhang Xuanping Zhang Yan Zhang Zhongming Zhao Lihua Zou Christian von Mering Steven Gallinger Lincoln D. Stein Lauri A. Aaltonen John R. McPherson Gad Getz Hiroyuki Aburatani David J. Adams Marcin Imieliński Keun Soo Ahn Sung-Min Ahn Alvin Wei Tian Ng Yuan Ji Kadir C. Akdemir Hikmat Al‐Ahmadie Sultan T. Al‐Sedairy Fátima Al‐Shahrour Malik Alawi Monique Albert Kenneth Aldape Florian Markowetz Adrian Ally Kathryn Alsop Eva G. Álvarez Fernanda Amary Samirkumar B. Amin Brice Aminou Ole Ammerpohl Matthew Anderson Yeng Ang Davide Antonello Pavana Anur Samuel Aparicio Elizabeth L. Appelbaum Yasuhito Arai Axel Aretz Koji Arihiro Shun‐ichi Ariizumi Joshua Armenia Laurent Arnould L. Sylvia Yassen Assenov Gurnit Atwal Sietse Aukema J. Todd Auman Rameen Beroukhim Chad J. Creighton Marta Aymerich Gary D. Bader Adrian Baez‐Ortega Matthew H. Bailey Peter J. Bailey Miruna Balasundaram Saianand Balu Pratiti Bandopadhayay Rosamonde E. Banks David C. Wedge Andrew P. 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Pearson Chandra Sekhar Pedamallu Jakob Skou Pedersen Paolo Pederzoli Martin Peifer Nathan A. Pennell Charles M. Perou Marc D. Perry Gloria M. Petersen Myron Peto Nicholas J. Petrelli Robert Petryszak Stefan M. Pfister Mark Phillips Oriol Pich Hilda A. Pickett Todd Pihl Nischalan Pillay Sarah Pinder Mark Pinese Andreia V. Pinho Esa Pitkänen Xavier Pivot Elena Piñeiro-Yáñez Laura Planko Christoph Plass Paz Polak Tirso Pons Irinel Popescu Olga Potapova Aparna Prasad Shaun R. Preston Manuel Prinz Antonia L. Pritchard Stephenie D. Prokopec Elena Provenzano Xosé S. Puente Sònia Puig Montserrat Puiggròs Sergio Pulido-Tamayo Gulietta M. Pupo Colin A. Purdie Michael C. Quinn Raquel Rabionet Janet S. Rader Bernhard Radlwimmer Petar Radovic Benjamin Raeder Keiran Raine Manasa Ramakrishna Kamna Ramakrishnan Suresh Ramalingam Benjamin J. Raphael W. Kimryn Rathmell Tobias Rausch Guido Reifenberger Jüri Reimand Jorge S. Reis‐Filho Victor E. Reuter Iker Reyes-Salazar Matthew A. Reyna Sheila M. 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Samra Francisco Sánchez-Vega Chris Sander Grant Sanders Rajiv Sarin Iman Sarrafi Aya Sasaki-Oku Torill Sauer Guido Sauter Robyn P.M. Saw Maria Scardoni Christopher J. Scarlett Aldo Scarpa Ghislaine Scélo Dirk Schadendorf Jacqueline E. Schein Markus B. Schilhabel Matthias Schlesner Thorsten Schlomm Heather K. Schmidt Sarah‐Jane Schramm Stefan Schreiber Nikolaus Schultz Steven E. Schumacher Roland F. Schwarz Richard A. Scolyer David W. Scott Ralph Scully Raja S. Seethala Ayellet V. Segrè Iris Selander Colin A. Semple Yasin Şenbabaoğlu Subhajit Sengupta Elisabetta Sereni Stefano Serra Dennis C. Sgroi Mark Shackleton Nimish Shah Sagedeh Shahabi Catherine A. Shang Peng Shang Ofer Shapira Troy Shelton Ciyue Shen Hui Shen Rebecca Shepherd Ruian Shi Yan Shi Yu-Jia Shiah Ana Milovanovic Juliann Shih Eigo Shimizu Kiyo Shimizu Seung-Jun Shin Yuichi Shiraishi Tal Shmaya Ilya Shmulevich Solomon I. Shorser Charles L. Short Raunak Shrestha Suyash Shringarpure Craig D. Shriver Shimin Shuai Gad Getz Reiner Siebert Anieta M. Sieuwerts Steven A. Roberts Sabina Signoretti Katarzyna Sikora Michele Simbolo Ronald Simon Janae V. Simons Jared T. Simpson Peter T. Simpson Samuel Singer Nasa Sinnott-Armstrong Payal Sipahimalani Tara Skelly Marcel Smid Jaclyn Smith Karen Smith‐McCune Nicholas D. Socci Heidi J. Sofia Matthew G. Soloway Lei Song Anil K. Sood Sharmila Sothi Christos Sotiriou Cameron M. Soulette Paul N. Span Paul T. Spellman Nicola Sperandio Andrew Spillane Oliver Spiro Jonathan Spring Johan Staaf Peter F. Stadler Peter Staib Stefan G. Stark Lucy Stebbings Ólafur Andri Stefánsson Oliver Stegle Lincoln D. Stein Alasdair Stenhouse Chip Stewart Stephan Stilgenbauer Miranda D. Stobbe Michael R. Stratton Jonathan R. Stretch Adam J. Struck Joshua M. Stuart Henk G. Stunnenberg Hong Su Xiaoping Su Ren Sun Stéphanie Sungalee Hana Sušak Akihiro Suzuki Fred C.G.J. Sweep Monika Szczepanowski Holger Sültmann Takashi Yugawa Angela Tam David Tamborero Benita Kiat Tee Tan Donghui Tan Patrick Tan Hiroko Tanaka Hirokazu Taniguchi Tomas Tanskanen Maxime Tarabichi Roy Tarnuzzer Patrick Tarpey Morgan L. Taschuk Kenji Tatsuno Simon Tavaré Darrin F. Taylor Amaro Taylor‐Weiner Jon W. Teague Bin Tean Teh Varsha Tembe Javier Temes Kevin Thai Sarah P. Thayer Nina Thiessen Gilles Thomas Sarah Thomas Alan Thompson Alastair M. Thompson John F. Thompson R. Houston Thompson Heather Thorne Leigh B. Thorne Adrian Thorogood Grace Tiao Nebojša Tijanić Lee E. Timms Roberto Tirabosco Marta Tojo Stefania Tommasi Christopher W. Toon Umut H. Toprak David Torrents Giampaolo Tortora Jörg Tost Yasushi Totoki David Townend Nadia Traficante Isabelle Treilleux Jakob Skou Pedersen Lorenz Trümper Ming‐Sound Tsao Tatsuhiko Tsunoda José M. C. Tubío Olga Tucker Richard Turkington Daniel J. Turner Andrew N.J. Tutt Masaki Ueno Naoto T. Ueno Christopher B. Umbricht Husen M. Umer Tim Underwood Mark Phillips Tomoko Urushidate Tetsuo Ushiku Liis Uusküla-Reimand Alfonso Valencia David J. Van Den Berg Steven Van Laere Peter Van Loo Erwin G. Van Meir Gert G. Van den Eynden Theodorus van der Kwast Naveen Vasudev Miguél Vázquez Ravikiran Vedururu Umadevi Veluvolu Shankar Vembu Lieven P. C. Verbeke Peter Vermeulen Clare Verrill Alain Viari David Vicente Caterina Vicentini K. VijayRaghavan Juris Vīksna Ricardo E. Vilain Izar Villasante Anne Vincent‐Salomon Tapio Visakorpi Douglas Voet Paresh Vyas Ignacio Vázquez-Garćıa Nick M. Waddell Nicola Waddell Claes Wadelius Lina Wadi Rabea Wagener Jeremiah A. Wala Jian Wang Jiayin Wang Linghua Wang Qi Wang Wei Lien Wang Yumeng Wang Zhining Wang Paul Waring Hans-Jörg Warnatz Jonathan Warrell Anne Y. Warren Sebastian M. Waszak David C. Wedge Dieter Weichenhan Paul Weinberger John N. Weinstein Davide Antonello Daniel J. Weisenberger Ian Welch Michael C. Wendl Johannes Werner Justin P. Whalley David A. Wheeler Hayley C. Whitaker Dennis A. Wigle Matthew D. Wilkerson Ashley Williams James S. Wilmott Gavin W. Wilson Julie M. Wilson Richard K. Wilson Boris Winterhoff Jeffrey A. Wintersinger Maciej Wiznerowicz Stephan Wolf Bernice H. Wong Tina Wong Winghing Wong Youngchoon Woo Scott Wood Bradly G. Wouters Adam J. Wright Derek W. Wright Mark H. Wright Chin‐Lee Wu Dai‐Ying Wu Guanming Wu Jianming Wu Kui Wu Yang Wu Zhenggang Wu Liu Xi Tian Xia Qian Xiang Xiao Xiao Rui Xing Heng Xiong Qingyu Xu Yanxun Xu Hong Xue Shinichi Yachida Sergei Yakneen Rui Yamaguchi Takafumi Yamaguchi Masakazu Yamamoto Shogo Yamamoto Hiroki Yamaue Fan Yang Huanming Yang Jean Yee Hwa Yang Liming Yang Lixing Yang Shanlin Yang Tsun-Po Yang Yang Yang Xiaotong Yao Marie‐Laure Yaspo Lucy Yates Christina Yau Hongzhi Wang Kai Ye Venkata D. Yellapantula Christopher J. Yoon Sung-Soo Yoon Fouad Yousif Jun Yu Kaixian Yu Willie Yu Yingyan Yu Ke Yuan Yuan Yuan Denis Yuen Christina K. Yung Olga Zaikova Jorge Zamora Marc Zapatka Jean C. Zenklusen Thorsten Zenz Nikolajs Zeps Chengzhong Zhang Fan Zhang Steven E. Schumacher Hongwei Zhang Hongxin Zhang Jiashan Zhang Jing Zhang Junjun Zhang Xiuqing Zhang Xuanping Zhang Yan Zhang Zemin Zhang Zhongming Zhao Liangtao Zheng Xunhua Zheng Wanding Zhou Yong Zhou Bin Zhu Jonas Demeulemeester Jingchun Zhu Shida Zhu Lihua Zou Xueqing Zou Anna deFazio Nicholas van As Carolien H.M. van Deurzen Ciyue Shen Ciyue Shen Christian von Mering published in 2020. It has an Open Access status of “gold”. You can read and download a PDF Full Text of this paper here.