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DOI: 10.1038/ng.801
¤ OpenAccess: Green
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Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
Adam C. Naj,Gyungah Jun,Gary W. Beecham,Li-San Wang,Badri N. Vardarajan,Jacqueline L. Buros,Paul J. Gallins,Joseph D. Buxbaum,Gail P. Jarvik,Paul K. Crane,Eric B. Larson,Thomas D. Bird,Bradley F. Boeve,Neill R. Graff‐Radford,Philip L. De Jager,Denis A. Evans,Julie A. Schneider,Minerva M. Carrasquillo,Nilüfer Ertekin-Taner,Steven G. Younkin,Carlos Cruchaga,John Kauwe,Petra Nowotny,Patricia L. Kramer,John Hardy,Matthew J. Huentelman,Amanda Myers,M. Michael Barmada,F. Yesim Demirci,Clinton T. Baldwin,Robert C Green,Ekaterina Rogaeva,Peter St George-Hyslop,Steven E. Arnold,Robert W. Barber,Thomas Beach,Eileen H. Bigio,James D. Bowen,Adam L. Boxer,James R. Burke,Nigel J. Cairns,Chris Carlson,Regina M. Carney,Steven Carroll,Helena C. Chui,David G. Clark,Jason J. Corneveaux,Carl W. Cotman,Jeffrey L. Cummings,Charles DeCarli,Steven T. DeKosky,Ramon Diaz‐Arrastia,Malcolm Dick,Dennis W. Dickson,William G. Ellis,Kelley Faber,Kenneth B. Fallon,Martin R. Farlow,Steven Ferris,Matthew P. Frosch,Douglas Galasko,Mary Ganguli,Marla Gearing,Daniel H. Geschwind,Bernardino Ghetti,John R. Gilbert,Sid Gilman,Bruno Giordani,Jonathan D. Glass,John H. Growdon,Ronald L. Hamilton,Lindy E. Harrell,Elizabeth Head,Lawrence S. Honig,Christine M. Hulette,Bradley T. Hyman,Gregory A. Jicha,Lee‐Way Jin,Nancy Johnson,Jason Karlawish,Anna Karydas,Jeffrey Kaye,Ronald Kim,Edward H. Koo,Neil W. Kowall,James J. Lah,Aĺlan I. Levey,Andrew P. Lieberman,Oscar L. López,Wendy J. Mack,Daniel C. Marson,Frank Martiniuk,Deborah C. Mash,Eliezer Masliah,Wayne C. McCormick,Susan M. McCurry,Andrew McDavid,Ann C. McKee,W Marsel Mesulam,Bruce L. Miller,Carol A. Miller,Joshua W. Miller,Joseph E. Parisi,Daniel P. Perl,Elaine R. Peskind,Ronald C. Petersen,Wayne W. Poon,Joseph F. Quinn,Ruchita Rajbhandary,Murray A. Raskind,Barry Reisberg,John M. Ringman,Erik D. Roberson,Roger N. Rosenberg,Mary Sano,Lon S. Schneider,William P. Seeley,Michael L. Shelanski,Michael A. Slifer,Charles D. Smith,Joshua A. Sonnen,Salvatore Spina,Robert A. Stern,Rudolph E. Tanzi,John Q. Trojanowski,Juan C. Troncoso,Vivianna M. Van Deerlin,Harry V. Vinters,Jean Paul Vonsattel,Sandra Weıntraub,Kathleen A. Welsh‐Bohmer,Jennifer Williamson,Randall L. Woltjer,Laura B. Cantwell,Beth A. Dombroski,Duane Beekly,Kathryn L. Lunetta,Eden R. Martin,M. Ilyas Kamboh,Andrew J. Saykin,Eric M. Reiman,David A. Bennett,John C. Morris,Thomas J. Montine,Alison M. Goate,Deborah Blacker,Debby W. Tsuang,Hákon Hákonarson,Walter A. Kukull,Tatiana Foroud,Jonathan L. Haines,Richard Mayeux,Margaret A. Pericak‐Vance,Lindsay A. Farrer,Gerard D. Schellenberg
Genome-wide association study
Biology
Meta-analysis
2011
The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and two replication stages (stages 2 and 3). Both joint analysis and meta-analysis approaches were used. We obtained genome-wide significant results at MS4A4A (rs4938933; stages 1 and 2, meta-analysis P (P(M)) = 1.7 × 10(-9), joint analysis P (P(J)) = 1.7 × 10(-9); stages 1, 2 and 3, P(M) = 8.2 × 10(-12)), CD2AP (rs9349407; stages 1, 2 and 3, P(M) = 8.6 × 10(-9)), EPHA1 (rs11767557; stages 1, 2 and 3, P(M) = 6.0 × 10(-10)) and CD33 (rs3865444; stages 1, 2 and 3, P(M) = 1.6 × 10(-9)). We also replicated previous associations at CR1 (rs6701713; P(M) = 4.6 × 10(-10), P(J) = 5.2 × 10(-11)), CLU (rs1532278; P(M) = 8.3 × 10(-8), P(J) = 1.9 × 10(-8)), BIN1 (rs7561528; P(M) = 4.0 × 10(-14), P(J) = 5.2 × 10(-14)) and PICALM (rs561655; P(M) = 7.0 × 10(-11), P(J) = 1.0 × 10(-10)), but not at EXOC3L2, to late-onset Alzheimer's disease susceptibility.
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“Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease” is a paper by Adam C. Naj Gyungah Jun Gary W. Beecham Li-San Wang Badri N. Vardarajan Jacqueline L. Buros Paul J. Gallins Joseph D. Buxbaum Gail P. Jarvik Paul K. Crane Eric B. Larson Thomas D. Bird Bradley F. Boeve Neill R. Graff‐Radford Philip L. De Jager Denis A. Evans Julie A. Schneider Minerva M. Carrasquillo Nilüfer Ertekin-Taner Steven G. Younkin Carlos Cruchaga John Kauwe Petra Nowotny Patricia L. Kramer John Hardy Matthew J. Huentelman Amanda Myers M. Michael Barmada F. Yesim Demirci Clinton T. Baldwin Robert C Green Ekaterina Rogaeva Peter St George-Hyslop Steven E. Arnold Robert W. Barber Thomas Beach Eileen H. Bigio James D. Bowen Adam L. Boxer James R. Burke Nigel J. Cairns Chris Carlson Regina M. Carney Steven Carroll Helena C. Chui David G. Clark Jason J. Corneveaux Carl W. Cotman Jeffrey L. Cummings Charles DeCarli Steven T. DeKosky Ramon Diaz‐Arrastia Malcolm Dick Dennis W. Dickson William G. Ellis Kelley Faber Kenneth B. Fallon Martin R. Farlow Steven Ferris Matthew P. Frosch Douglas Galasko Mary Ganguli Marla Gearing Daniel H. Geschwind Bernardino Ghetti John R. Gilbert Sid Gilman Bruno Giordani Jonathan D. Glass John H. Growdon Ronald L. Hamilton Lindy E. Harrell Elizabeth Head Lawrence S. Honig Christine M. Hulette Bradley T. Hyman Gregory A. Jicha Lee‐Way Jin Nancy Johnson Jason Karlawish Anna Karydas Jeffrey Kaye Ronald Kim Edward H. Koo Neil W. Kowall James J. Lah Aĺlan I. Levey Andrew P. Lieberman Oscar L. López Wendy J. Mack Daniel C. Marson Frank Martiniuk Deborah C. Mash Eliezer Masliah Wayne C. McCormick Susan M. McCurry Andrew McDavid Ann C. McKee W Marsel Mesulam Bruce L. Miller Carol A. Miller Joshua W. Miller Joseph E. Parisi Daniel P. Perl Elaine R. Peskind Ronald C. Petersen Wayne W. Poon Joseph F. Quinn Ruchita Rajbhandary Murray A. Raskind Barry Reisberg John M. Ringman Erik D. Roberson Roger N. Rosenberg Mary Sano Lon S. Schneider William P. Seeley Michael L. Shelanski Michael A. Slifer Charles D. Smith Joshua A. Sonnen Salvatore Spina Robert A. Stern Rudolph E. Tanzi John Q. Trojanowski Juan C. Troncoso Vivianna M. Van Deerlin Harry V. Vinters Jean Paul Vonsattel Sandra Weıntraub Kathleen A. Welsh‐Bohmer Jennifer Williamson Randall L. Woltjer Laura B. Cantwell Beth A. Dombroski Duane Beekly Kathryn L. Lunetta Eden R. Martin M. Ilyas Kamboh Andrew J. Saykin Eric M. Reiman David A. Bennett John C. Morris Thomas J. Montine Alison M. Goate Deborah Blacker Debby W. Tsuang Hákon Hákonarson Walter A. Kukull Tatiana Foroud Jonathan L. Haines Richard Mayeux Margaret A. Pericak‐Vance Lindsay A. Farrer Gerard D. Schellenberg published in 2011. It has an Open Access status of “green”. You can read and download a PDF Full Text of this paper here.