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DOI: 10.1038/ng.444
¤ OpenAccess: Green
This work has “Green” OA status. This means it may cost money to access on the publisher landing page, but there is a free copy in an OA repository.
Identification of a new prostate cancer susceptibility locus on chromosome 8q24
Meredith Yeager,Nilanjan Chatterjee,Julia Ciampa,Kevin B. Jacobs,Jesús González Bosquet,Richard B. Hayes,Peter Kraft,Sholom Wacholder,Nick Orr,Sonja I. Berndt,Kai Yu,Amy Hutchinson,Zhaoming Wang,Laufey T. Ámundadóttir,Heather Spencer Feigelson,Michael J. Thun,W. Ryan Diver,Demetrius Albanês,Jarmo Virtamo,Stephanie J. Weinstein,Fredrick Schumacher,Géraldine Cancel‐Tassin,Olivier Cussenot,Antoine Valéri,Gerald L. Andriole,E. David Crawford,Christopher A. Haiman,Brian E. Henderson,Laurence Kolonel,Loı̈c Le Marchand,Afshan Siddiq,Elio Ríboli,Timothy J. Key,Rudolf Kaaks,William B. Isaacs,Sarah D. Isaacs,Kathleen E. Wiley,Henrik Grönberg,Fredrik Wiklund,Pär Stattin,Jianfeng Xu,S. Lilly Zheng,Jielin Sun,Lars J. Vatten,Kristian Hveem,Merethe Kumle,Margaret A. Tucker,Daniela S. Gerhard,Robert N. Hoover,Joseph F. Fraumeni,David J. Hunter,Gilles Thomas,Stephen J. Chanock
Locus (genetics)
Prostate cancer
Biology
2009
Meredith Yeager and colleagues with the Cancer Genetics Markers of Susceptibility (CGEMS) initiative report a new association to prostate cancer at chromosome 8q24. This defines a new locus, region 4, which shows association to prostate cancer susceptibility independent of previously reported associations at 8q24. We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 × 10−10, heterozygote OR = 1.17, 95% CI 1.10–1.24; homozygote OR = 1.33, 95% CI 1.21–1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.
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“Identification of a new prostate cancer susceptibility locus on chromosome 8q24” is a paper by Meredith Yeager Nilanjan Chatterjee Julia Ciampa Kevin B. Jacobs Jesús González Bosquet Richard B. Hayes Peter Kraft Sholom Wacholder Nick Orr Sonja I. Berndt Kai Yu Amy Hutchinson Zhaoming Wang Laufey T. Ámundadóttir Heather Spencer Feigelson Michael J. Thun W. Ryan Diver Demetrius Albanês Jarmo Virtamo Stephanie J. Weinstein Fredrick Schumacher Géraldine Cancel‐Tassin Olivier Cussenot Antoine Valéri Gerald L. Andriole E. David Crawford Christopher A. Haiman Brian E. Henderson Laurence Kolonel Loı̈c Le Marchand Afshan Siddiq Elio Ríboli Timothy J. Key Rudolf Kaaks William B. Isaacs Sarah D. Isaacs Kathleen E. Wiley Henrik Grönberg Fredrik Wiklund Pär Stattin Jianfeng Xu S. Lilly Zheng Jielin Sun Lars J. Vatten Kristian Hveem Merethe Kumle Margaret A. Tucker Daniela S. Gerhard Robert N. Hoover Joseph F. Fraumeni David J. Hunter Gilles Thomas Stephen J. Chanock published in 2009. It has an Open Access status of “green”. You can read and download a PDF Full Text of this paper here.