Thyroid Function Tests Simulating Graves' Disease in Alcoholic Hepatitis

Brief Reports1 October 1978Thyroid Function Tests Simulating Graves' Disease in Alcoholic HepatitisDAVID D. STUART, M.D., ALVIN L. SCHULTZ, M.D., F.A.C.P.DAVID D. STUART, M.D.Search for more papers by this author, ALVIN L. SCHULTZ, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-4-514 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe liver may be a major site of extrathyroidal conversion of thyroxine (T4) to triiodothyronine (T3). Patients with alcoholic liver disease of several types have been observed to have mild but significant elevations of serum thyrotropin (TSH) and free T4, and normal or low free T3compared with control populations (1, 2). Estimated T3production rate in patients with hepatic cirrhosis is substantially less than that of normal persons, whereas the production rate of reverse T3is unchanged (3). These observations suggest that, in patients with liver disease, a compensatory increase in TSH and in thyroidal hormonogenesis occurs in response...References1. NOMURAPITTMANCHAMBERSBUCKSHIMIZU SCJMT: Reduced peripheral conversion of thyroxine to triiodothyronine in patients with hepatic cirrhosis. J Clin Invest 56:643-652, 1975 CrossrefMedlineGoogle Scholar2. CHOPRASOLOMONCHOPRAYOUNGCHUA TECO IDURG: Thyroid hormones and thyrotropin in hepatic cirrhosis. Evidence for euthyroidism despite subnormal serum triiodothyronine. J Clin Endocrinol Metab 39:501-511, 1974 CrossrefMedlineGoogle Scholar3. CHOPRA I: An assessment of daily production and significance of thyroidal secretion of 3,3′, 5′-triiodothyronine (reverse T3) in man. J Clin Invest 58:32-40, 1976 CrossrefMedlineGoogle Scholar4. WONGSCHULTZ EA: Changing values for the normal thyroid radioactive iodine uptake test. JAMA 238:1741-1743, 1977 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hennepin County Medical Center The University of Minnesota Medical School Minneapolis, Minnesota PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAlcohol, Hormones, and MetabolismChanges in thyroid function tests in physical and psychiatric diseasesThyroid Hormones and the LiverEffects of Chronic Ethanol Administration on 0 2 Consumption in Whole Body and Perfused Liver of the RatAssessment of Thyroid Function in Chronic Alcoholics 1 October 1978Volume 89, Issue 4Page: 514-515KeywordsAlcoholicsCirrhosisHepatitis ALiverLiver diseasesPopulation statisticsThyroidThyroid-stimulating hormoneThyroxineTriiodothyronine Issue Published: 1 October 1978 PDF DownloadLoading ...