¤ OpenAccess: Gold

This work has “Gold” OA status. This means it is published in an Open Access journal that is indexed by the DOAJ.

Knockdown of LncRNA <i>RHPN1-AS1</i> Inhibits Cell Migration, Invasion and Proliferation in Head and Neck Squamous Cell Carcinoma

Xiaowen Qiu,Lang Zhuo,Zeyou Wang,Yuming Xu,Chang Liu,Panchun Li,Hanjiang Wu,Zhaojian Gong

Gene knockdown

Head and neck squamous-cell carcinoma

Cancer research

2019

Previous studies have revealed that long non-coding RNAs (lncRNAs) are involved in head and neck squamous cell carcinoma (HNSCC) progression.However, the detailed roles of lncRNA RHPN1-AS1 remain to be elucidated.In this study, by analyzing online RNA-Seq data, we found that RHPN1-AS1 was upregulated in HNSCC tissues and that its expression level was associated with neoplasm histologic grade.High expression of RHPN1-AS1 was also confirmed in HNSCC tissues.Knockdown of RHPN1-AS1 inhibited tumor cell migration, invasion and proliferation in HNSCC.Furthermore, inhibition of RHPN1-AS1 suppressed the expression of epithelial-mesenchymal transition (EMT)-related genes (β-Catenin, Claudin-1 and Vimentin) in HNSCC cells.Collectively, our results suggest that RHPN1-AS1, acting as an oncogene, may be a potential diagnostic and therapeutic target in HNSCC.

Cite this:

Generate Citation

“Knockdown of LncRNA <i>RHPN1-AS1</i> Inhibits Cell Migration, Invasion and Proliferation in Head and Neck Squamous Cell Carcinoma” is a paper by Xiaowen Qiu Lang Zhuo Zeyou Wang Yuming Xu Chang Liu Panchun Li Hanjiang Wu Zhaojian Gong published in 2019. It has an Open Access status of “gold”. You can read and download a PDF Full Text of this paper here.