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Stimulation of ALK by the growth factor midkine renders glioma cells resistant to autophagy-mediated cell death

Mar Lorente,Sofía Torres,María Salazar,Arkaitz Carracedo,Sonia Hernández‐Tiedra,Fátima Rodríguez-Fornés,Elena García-Taboada,Bárbara Meléndez,Manuela Mollejo,Yolanda Campos‐Martín,Juan A. Barcia,Manuel Guzmán,Guillermo Velasco

Midkine

Autophagy

Biology

2011

Δ9-tetrahydrocannabinol (THC), the main active component of marijuana, promotes cancer cell death via autophagy stimulation. We find that activation of the tyrosine kinase receptor ALK by its ligand midkine interferes with the signaling mechanism by which THC promotes autophagy-mediated glioma cell death.

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“Stimulation of ALK by the growth factor midkine renders glioma cells resistant to autophagy-mediated cell death” is a paper by Mar Lorente Sofía Torres María Salazar Arkaitz Carracedo Sonia Hernández‐Tiedra Fátima Rodríguez-Fornés Elena García-Taboada Bárbara Meléndez Manuela Mollejo Yolanda Campos‐Martín Juan A. Barcia Manuel Guzmán Guillermo Velasco published in 2011. It has an Open Access status of “bronze”. You can read and download a PDF Full Text of this paper here.