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DOI: 10.3390/fluids8050159
¤ OpenAccess: Gold
This work has “Gold” OA status. This means it is published in an Open Access journal that is indexed by the DOAJ.

Modelling The Hemodynamics of Coronary Ischemia

Abdulaziz Al Baraikan,K. Czechowicz,Paul D Morris,Ian Halliday,Rebecca Gosling,Julian Gunn,Andrew Narracott,Gareth Williams,Pankaj Garg,Maciej Malawski,F.N. van de Vosse,Angela Lungu,D. Rafiroiu,D. Rodney Hose

Cardiology
Ischemia
Coronary artery disease
2023
Acting upon clinical patient data, acquired in the pathway of percutaneous intervention, we deploy hierarchical, multi-stage, data-handling protocols and interacting low- and high-order mathematical models (chamber elastance, state-space system and CFD models), to establish and then validate a framework to quantify the burden of ischaemia. Our core tool is a compartmental, zero-dimensional model of the coupled circulation with four heart chambers, systemic and pulmonary circulations and an optimally adapted windkessel model of the coronary arteries that reflects the diastolic dominance of coronary flow. We guide the parallel development of protocols and models by appealing to foundational physiological principles of cardiac energetics and a parameterisation (stenotic Bernoulli resistance and micro-vascular resistance) of patients’ coronary flow. We validate our process first with results which substantiate our protocols and, second, we demonstrate good correspondence between model operation and patient data. We conclude that our core model is capable of representing (patho)physiological states and discuss how it can potentially be deployed, on clinical data, to provide a quantitative assessment of the impact, on the individual, of coronary artery disease.
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    Modelling The Hemodynamics of Coronary Ischemia” is a paper by Abdulaziz Al Baraikan K. Czechowicz Paul D Morris Ian Halliday Rebecca Gosling Julian Gunn Andrew Narracott Gareth Williams Pankaj Garg Maciej Malawski F.N. van de Vosse Angela Lungu D. Rafiroiu D. Rodney Hose published in 2023. It has an Open Access status of “gold”. You can read and download a PDF Full Text of this paper here.