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DOI: 10.3389/fonc.2014.00385
¤ OpenAccess: Gold
This work has “Gold” OA status. This means it is published in an Open Access journal that is indexed by the DOAJ.
CTLA-4 and PD-1 Pathway Blockade: Combinations in the Clinic
Margaret K. Callahan,Michael A. Postow,Jedd D. Wolchok
Blockade
Immunotherapy
Blocking (statistics)
2015
Checkpoint blocking antibodies targeting regulatory molecules on T cells such as CTLA-4 and PD-1 have reinvigorated the field of cancer immunotherapy. These agents have demonstrated clinical activity across a variety of tumor types. Now that safety and clinical activity has been demonstrated in the monotherapy setting, the field is moving in the direction of testing novel combinations.
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“CTLA-4 and PD-1 Pathway Blockade: Combinations in the Clinic” is a paper by Margaret K. Callahan Michael A. Postow Jedd D. Wolchok published in 2015. It has an Open Access status of “gold”. You can read and download a PDF Full Text of this paper here.