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Exemestane encapsulated vitamin E-TPGS–polymeric nanoparticles: preparation, optimization, characterization, and <i>in vitro</i> cytotoxicity assessment

Brahmeshwar Mishra,Ravi Padaliya,Ravi R. Patel

Cytotoxicity

Materials science

Nanoparticle

2016

The objective of the present study was to formulate and optimize exemestane (EXM) encapsulated vitamin E-TPGS-poly-ɛ-caprolactone based polymeric nanoparticles (TPGS-PCLNPs) for enhancing its anticancer efficacy. The 23 factorial design was employed to investigate the combined influence of formulation and process variables on properties of TPGS-PCLNPs, prepared by nanoprecipitation method. The physicochemical characterization revealed the encapsulation of EXM in amorphous form without any interaction inside spherical shaped TPGS-PCLNPs. In vitro cytotoxicity study on MCF-7 breast cancer cells exhibited enhanced cytotoxicity of EXM by encapsulating in TPGS-PCLNPs. The TPGS-PCLNPs can serve as potential delivery vehicle for EXM to improve its therapeutic efficacy.

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“Exemestane encapsulated vitamin E-TPGS–polymeric nanoparticles: preparation, optimization, characterization, and <i>in vitro</i> cytotoxicity assessment” is a paper by Brahmeshwar Mishra Ravi Padaliya Ravi R. Patel published in 2016. It has an Open Access status of “bronze”. You can read and download a PDF Full Text of this paper here.