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Sensory abnormalities in unaffected relatives in familial adult-onset dystonia

John Philip O'Dwyer,Sean O’Riordan,Rachel Saunders‐Pullman,Susan Bressman,Fiona Molloy,Tim Lynch,Michael Hutchinson

Endophenotype

Somatosensory system

Medicine

2005

Somatosensory abnormalities are found in adult-onset primary torsion dystonia (PTD). Therefore we assessed spatial discrimination thresholds (SDT), a measure of spatial acuity, in four multiplex families with adult-onset PTD. In family members aged 20 to 45 years vs controls (mean + 2.5 SD), abnormal SDTs were found in four of five affected with adult-onset PTD and in 12 of 49 unaffected relatives. Sensory abnormalities may be an endophenotype, possibly expressed later as adult-onset PTD.

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“Sensory abnormalities in unaffected relatives in familial adult-onset dystonia” is a paper by John Philip O'Dwyer Sean O’Riordan Rachel Saunders‐Pullman Susan Bressman Fiona Molloy Tim Lynch Michael Hutchinson published in 2005. It has an Open Access status of “closed”. You can read and download a PDF Full Text of this paper here.