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DOI: 10.1186/s13244-019-0764-0
¤ OpenAccess: Gold
This work has “Gold” OA status. This means it is published in an Open Access journal that is indexed by the DOAJ.

Validated imaging biomarkers as decision-making tools in clinical trials and routine practice: current status and recommendations from the EIBALL* subcommittee of the European Society of Radiology (ESR)

Nandita M. deSouza,Eric Achten,Ángel Alberich-Bayarri,Fabian Bamberg,Ronald Boellaard,Olivier Clémеnt,Laure Fournier,Ferdia A. Gallagher,Xavier Golay,Claus Peter Heußel,Edward F. Jackson,Rashindra Manniesing,Marius E. Mayerhoefer,Emanuele Neri,James P.B. O’Connor,Kader Karlı Oğuz,Anders Persson,Marion Smits,Edwin Jacques Rudolph van Beek,Christoph J. Zech

Medicine
Neuroradiology
Medical physics
2019
Observer-driven pattern recognition is the standard for interpretation of medical images. To achieve global parity in interpretation, semi-quantitative scoring systems have been developed based on observer assessments; these are widely used in scoring coronary artery disease, the arthritides and neurological conditions and for indicating the likelihood of malignancy. However, in an era of machine learning and artificial intelligence, it is increasingly desirable that we extract quantitative biomarkers from medical images that inform on disease detection, characterisation, monitoring and assessment of response to treatment. Quantitation has the potential to provide objective decision-support tools in the management pathway of patients. Despite this, the quantitative potential of imaging remains under-exploited because of variability of the measurement, lack of harmonised systems for data acquisition and analysis, and crucially, a paucity of evidence on how such quantitation potentially affects clinical decision-making and patient outcome. This article reviews the current evidence for the use of semi-quantitative and quantitative biomarkers in clinical settings at various stages of the disease pathway including diagnosis, staging and prognosis, as well as predicting and detecting treatment response. It critically appraises current practice and sets out recommendations for using imaging objectively to drive patient management decisions.
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    Validated imaging biomarkers as decision-making tools in clinical trials and routine practice: current status and recommendations from the EIBALL* subcommittee of the European Society of Radiology (ESR)” is a paper by Nandita M. deSouza Eric Achten Ángel Alberich-Bayarri Fabian Bamberg Ronald Boellaard Olivier Clémеnt Laure Fournier Ferdia A. Gallagher Xavier Golay Claus Peter Heußel Edward F. Jackson Rashindra Manniesing Marius E. Mayerhoefer Emanuele Neri James P.B. O’Connor Kader Karlı Oğuz Anders Persson Marion Smits Edwin Jacques Rudolph van Beek Christoph J. Zech published in 2019. It has an Open Access status of “gold”. You can read and download a PDF Full Text of this paper here.