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Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Massimo Sartelli,Dieter Weber,Étienne Ruppé,Matteo Bassetti,Brian J. Wright,Luca Ansaloni,Fausto Catena,Federico Coccolini,Fikri M. Abu‐Zidan,Raúl Coimbra,Ernest E. Moore,Frederick A. Moore,Ronald V. Maier,Jan J. De Waele,Andrew W. Kirkpatrick,Ewen A. Griffiths,Christian Eckmann,Adrian Brink,John E. Mazuski,Addison K. May,Robert G. Sawyer,Dominik Mertz,Philippe Montravers,Anand Kumar,Jason A. Roberts,Jean–Louis Vincent,Richard Watkins,Warren Lowman,Brad Spellberg,Iain J. Abbott,A. R. K. Adesunkanmi,Sara Al-Dahir,Majdi N. Al-Hasan,Ferdinando Agresta,Asma Althani,Shamshul Ansari,Rashid Ansumana,Goran Augustin,Miklosh Bala,Zsolt J. Balogh,Oussama Baraket,Aneel Bhangu,Marcelo A. Beltrán,Michaël Bernhard,Walter L. Biffl,Marja A. Boermeester,Stephen M. Brecher,Jill R. Cherry-Bukowiec,Otmar R. Buyne,Miguel Caínzos,Kelly A. Cairns,Adrián Camacho-Ortíz,Sujith J Chandy,Asri Che Jusoh,Alain Chichom Mefire,Caroline Colijn,Francesco Corcione,Cui Y,Daniel Curcio,Samir Delibegović,Zaza Demetrashvili,Belinda De Simone,Swati Dhingra,José J. Diaz,Isidoro Di Carlo,Angel Dillip,Salomone Di Saverio,Michael P. Doyle,Gereltuya Dorj,Agron Dogjani,Hervé Dupont,Soumitra R. Eachempati,Mushira Enani,В Н Егиев,Mutasim M. Elmangory,Paula Ferrada,Joseph R Fitchett,Gustavo Pereira Fraga,Nathalie Guessennd,Helen Giamarellou,Wagih Mommtaz Ghnnam,George Gkiokas,Sarah Goldberg,Carlos Augusto Gomes,Harumi Gomi,Manuel Guzmán-Blanco,Mainul Haque,Sonja Hansen,Andreas Hecker,W. Heizmann,Torsten Herzog,Adrien M. Hodonou,Suk Kyung Hong,Reinhold Kafka-Ritsch,Lewis J. Kaplan,Garima Kapoor,Aleksandar Karamarković,Martin G. Kees,Jakub Kenig,Ronald Kiguba,Peter K. Kim,Yoram Kluger,Vladimir Khokha,Kazuhiko Koike,Kenneth Y. Y. Kok,V Y Kong,Matthew C. Knox,Kenji Inaba,Arda Işık,Katia Iskandar,Rao R. Ivatury,Maurizio Labbate,Francesco M. Labricciosa,Pierre François Laterre,Rifat Latifi,Jae-Gil Lee,Young Ran Lee,Marc Léone,Ari Leppäniemi,Yousheng Li,Stephen Y. Liang,Tonny Loho,Marc Maegele,Sydney Malama,Hany E. Marei,Ignacio Martín‐Loeches,Sanjay Marwah,Amos Massele,Michael McFarlane,Renato Bessa Melo,Ionuţ Negoi,David P. Nicolau,Carl Erik Nord,Richard Ofori‐Asenso,Abdel K. Omari,Carlos A. Ordóñez,Ouadii Mouaqit,Gerson Alves Pereira Júnior,Diego Piazza,Guntars Pupelis,Timothy M. Rawson,Miran Rems,Sandro Rizoli,Claudio Rocha,Boris Sakakhushev,Miguel Sánchez-García,Norio Sato,Helmut Alfredo Segovia Lohse,Gabriele Sganga,Boonying Siribumrungwong,Vishal G Shelat,Kjetil Søreide,Rodolfo Soto,Peep Talving,Jonathan Tilsed,Jean François Timsit,Gabriel Trueba,Ngo Tat Trung,Jan Ulrych,Harry van Goor,András Vereczkei,Ravinder Vohra,Imtiaz Wani,Waldemar Uhl,Yonghong Xiao,Kuo Ching Yuan,Sanoop Koshy Zachariah,Jean Ralph Zahar,Tanya L. Zakrison,Antonio Corcione,Rita Maria Melotti,Claudio Viscoli,P Viale

Medicine

Intensive care medicine

Antimicrobial

2016

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.

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“Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)” is a paper by Massimo Sartelli Dieter Weber Étienne Ruppé Matteo Bassetti Brian J. Wright Luca Ansaloni Fausto Catena Federico Coccolini Fikri M. Abu‐Zidan Raúl Coimbra Ernest E. Moore Frederick A. Moore Ronald V. Maier Jan J. De Waele Andrew W. Kirkpatrick Ewen A. Griffiths Christian Eckmann Adrian Brink John E. Mazuski Addison K. May Robert G. Sawyer Dominik Mertz Philippe Montravers Anand Kumar Jason A. Roberts Jean–Louis Vincent Richard Watkins Warren Lowman Brad Spellberg Iain J. Abbott A. R. K. Adesunkanmi Sara Al-Dahir Majdi N. Al-Hasan Ferdinando Agresta Asma Althani Shamshul Ansari Rashid Ansumana Goran Augustin Miklosh Bala Zsolt J. Balogh Oussama Baraket Aneel Bhangu Marcelo A. Beltrán Michaël Bernhard Walter L. Biffl Marja A. Boermeester Stephen M. Brecher Jill R. Cherry-Bukowiec Otmar R. Buyne Miguel Caínzos Kelly A. Cairns Adrián Camacho-Ortíz Sujith J Chandy Asri Che Jusoh Alain Chichom Mefire Caroline Colijn Francesco Corcione Cui Y Daniel Curcio Samir Delibegović Zaza Demetrashvili Belinda De Simone Swati Dhingra José J. Diaz Isidoro Di Carlo Angel Dillip Salomone Di Saverio Michael P. Doyle Gereltuya Dorj Agron Dogjani Hervé Dupont Soumitra R. Eachempati Mushira Enani В Н Егиев Mutasim M. Elmangory Paula Ferrada Joseph R Fitchett Gustavo Pereira Fraga Nathalie Guessennd Helen Giamarellou Wagih Mommtaz Ghnnam George Gkiokas Sarah Goldberg Carlos Augusto Gomes Harumi Gomi Manuel Guzmán-Blanco Mainul Haque Sonja Hansen Andreas Hecker W. Heizmann Torsten Herzog Adrien M. Hodonou Suk Kyung Hong Reinhold Kafka-Ritsch Lewis J. Kaplan Garima Kapoor Aleksandar Karamarković Martin G. Kees Jakub Kenig Ronald Kiguba Peter K. Kim Yoram Kluger Vladimir Khokha Kazuhiko Koike Kenneth Y. Y. Kok V Y Kong Matthew C. Knox Kenji Inaba Arda Işık Katia Iskandar Rao R. Ivatury Maurizio Labbate Francesco M. Labricciosa Pierre François Laterre Rifat Latifi Jae-Gil Lee Young Ran Lee Marc Léone Ari Leppäniemi Yousheng Li Stephen Y. Liang Tonny Loho Marc Maegele Sydney Malama Hany E. Marei Ignacio Martín‐Loeches Sanjay Marwah Amos Massele Michael McFarlane Renato Bessa Melo Ionuţ Negoi David P. Nicolau Carl Erik Nord Richard Ofori‐Asenso Abdel K. Omari Carlos A. Ordóñez Ouadii Mouaqit Gerson Alves Pereira Júnior Diego Piazza Guntars Pupelis Timothy M. Rawson Miran Rems Sandro Rizoli Claudio Rocha Boris Sakakhushev Miguel Sánchez-García Norio Sato Helmut Alfredo Segovia Lohse Gabriele Sganga Boonying Siribumrungwong Vishal G Shelat Kjetil Søreide Rodolfo Soto Peep Talving Jonathan Tilsed Jean François Timsit Gabriel Trueba Ngo Tat Trung Jan Ulrych Harry van Goor András Vereczkei Ravinder Vohra Imtiaz Wani Waldemar Uhl Yonghong Xiao Kuo Ching Yuan Sanoop Koshy Zachariah Jean Ralph Zahar Tanya L. Zakrison Antonio Corcione Rita Maria Melotti Claudio Viscoli P Viale published in 2016. It has an Open Access status of “gold”. You can read and download a PDF Full Text of this paper here.