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A scalable, fully automated process for construction of sequence-ready human exome targeted capture libraries

Sheila Fisher,Andrew Barry,Justin Abreu,Brian Minie,Jillian Nolan,Toni Delorey,Geneva Young,Timothy Fennell,Alex Allen,Lauren Ambrogio,Aaron M. Berlin,Brendan Blumenstiel,Kristian Cibulskis,Dennis Friedrich,Ryan C. Johnson,Frank Juhn,Brian Reilly,Ramy Shammas,John Stalker,Sean M. Sykes,Jon S. Thompson,John Walsh,Andrew Zimmer,Zac Zwirko,Stacey Gabriel,Robert Nicol,Chad Nusbaum

Scalability

Computer science

Process (computing)

2011

Genome targeting methods enable cost-effective capture of specific subsets of the genome for sequencing. We present here an automated, highly scalable method for carrying out the Solution Hybrid Selection capture approach that provides a dramatic increase in scale and throughput of sequence-ready libraries produced. Significant process improvements and a series of in-process quality control checkpoints are also added. These process improvements can also be used in a manual version of the protocol.

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“A scalable, fully automated process for construction of sequence-ready human exome targeted capture libraries” is a paper by Sheila Fisher Andrew Barry Justin Abreu Brian Minie Jillian Nolan Toni Delorey Geneva Young Timothy Fennell Alex Allen Lauren Ambrogio Aaron M. Berlin Brendan Blumenstiel Kristian Cibulskis Dennis Friedrich Ryan C. Johnson Frank Juhn Brian Reilly Ramy Shammas John Stalker Sean M. Sykes Jon S. Thompson John Walsh Andrew Zimmer Zac Zwirko Stacey Gabriel Robert Nicol Chad Nusbaum published in 2011. It has an Open Access status of “hybrid”. You can read and download a PDF Full Text of this paper here.