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DOI: 10.1161/01.res.0000260250.83824.8f
¤ OpenAccess: Bronze
This work has “Bronze” OA status. This means it is free to read on the publisher landing page, but without any identifiable license.

Regulation of Endocytic Recycling of KCNQ1/KCNE1 Potassium Channels

Guiscard Seebohm,Nathalie Strutz‐Seebohm,Ria Birkin,Ghislaine Dell,Cecilia Bucci,Maria Rita Spinosa,Ravshan Baltaev,Andreas F. Mack,Ganna Korniychuk,Amit Choudhury,David L. Marks,Richard E. Pagano,Bernard Attali,Arne Pfeufer,Robert S. Kass,Michael C. Sanguinetti,Jeremy M. Tavaré,Florian Läng

Exocytosis
Endocrinology
Internal medicine
2007
Stress-dependent regulation of cardiac action potential duration is mediated by the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis. It is accompanied by an increased magnitude of the slow outward potassium ion current, I(Ks). KCNQ1 and KCNE1 subunits coassemble to form the I(Ks) channel. Mutations in either subunit cause long QT syndrome, an inherited cardiac arrhythmia associated with an increased risk of sudden cardiac death. Here we demonstrate that exocytosis of KCNQ1 proteins to the plasma membrane requires the small GTPase RAB11, whereas endocytosis is dependent on RAB5. We further demonstrate that RAB-dependent KCNQ1/KCNE1 exocytosis is enhanced by the serum- and glucocorticoid-inducible kinase 1, and requires phosphorylation and activation of phosphoinositide 3-phosphate 5-kinase and the generation of PI(3,5)P(2). Identification of KCNQ1/KCNE1 recycling and its modulation by serum- and glucocorticoid-inducible kinase 1-phosphoinositide 3-phosphate 5-kinase -PI(3,5)P(2) provides a mechanistic insight into stress-induced acceleration of cardiac repolarization.
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    Regulation of Endocytic Recycling of KCNQ1/KCNE1 Potassium Channels” is a paper by Guiscard Seebohm Nathalie Strutz‐Seebohm Ria Birkin Ghislaine Dell Cecilia Bucci Maria Rita Spinosa Ravshan Baltaev Andreas F. Mack Ganna Korniychuk Amit Choudhury David L. Marks Richard E. Pagano Bernard Attali Arne Pfeufer Robert S. Kass Michael C. Sanguinetti Jeremy M. Tavaré Florian Läng published in 2007. It has an Open Access status of “bronze”. You can read and download a PDF Full Text of this paper here.