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DOI: 10.1155/2018/9594568
¤ OpenAccess: Gold
This work has “Gold” OA status. This means it is published in an Open Access journal that is indexed by the DOAJ.

Association of p16 as Prognostic Factors for Oropharyngeal Cancer: Evaluation of p16 in 1470 Patients for a 16 Year Study in Northeast China

Hongxue Meng,Susheng Miao,Kexin Chen,Huining Li,Guo‐Dong Yao,Jiashi Geng,Hongmei Wang,Qingli Shi,Jing He,Xionghui Mao,Fangjia Tong,Lanlan Wei,Ji Sun,Dongfeng Tan,Qian You,Xiaomei Li

Concordance
Medicine
Etiology
2018
Human papillomavirus (HPV) is an etiological risk factor for oropharyngeal squamous cell carcinomas (OPSCC). Our study investigates the prevalence, prognostic, and clinicopathologic features of HPV-related oropharyngeal cancer in Northeast China and elucidates the involvement of p16 in the tumorigenesis and progression of OPSCC. Specimens from 1470 OPSCC patients collected from 2000 to 2016 were analyzed using the status of HPV by polymerase chain reaction (PCR) and p16 immunohistochemistry. Overexpression of p16 was observed in 81 (5.51%) of the 1470 cases, and HPV positive was present in 78 cases (5.31%) of the 1470 cases. HPV positive and p16 overexpression have a good concordance. However, we found that the etiological fraction of HPV in cancers of the OPSCCs was obviously lower in Northeast China than other cohorts previously reported. Interestingly, nearly 89% of patients with p16 expression were smokers, and nearly 70% of patients with p16 expression had a history of alcohol. Our study also demonstrates that p16 expression is significantly associated with early stage primary OPSCCs and the patients with p16 expression tend to show better survival following surgery and radiotherapy.
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    Association of p16 as Prognostic Factors for Oropharyngeal Cancer: Evaluation of p16 in 1470 Patients for a 16 Year Study in Northeast China” is a paper by Hongxue Meng Susheng Miao Kexin Chen Huining Li Guo‐Dong Yao Jiashi Geng Hongmei Wang Qingli Shi Jing He Xionghui Mao Fangjia Tong Lanlan Wei Ji Sun Dongfeng Tan Qian You Xiaomei Li published in 2018. It has an Open Access status of “gold”. You can read and download a PDF Full Text of this paper here.