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Metagenomic sequencing at the epicenter of the Nigeria 2018 Lassa fever outbreak

Liana E. Kafetzopoulou,Steven T. Pullan,Philippe Lemey,Marc A. Suchard,Deborah U. Ehichioya,Meike Pahlmann,Anke Thielebein,Julia Hinzmann,Lisa Oestereich,David M. Wozniak,Kyriakos Efthymiadis,D Schachten,F. O. Koenig,J Matjeschk,Stephan Lorenzen,Sarah Lumley,Yemisi Ighodalo,Donatus I Adomeh,Thomas Olokor,Emmanuel Omomoh,Racheal Omiunu,Jacqueline Agbukor,Benevolence Ebo,John Aiyepada,Paulson Ebhodaghe,Osiemi Blessing,Solomon Ehikhametalor,Patience Akhilomen,Michael Airende,R Esumeh,Ekene Muoebonam,Rosemary Giwa,Ekanem Anieno,Ganiyu Igenegbale,George Odigie,Grace Okonofua,Racheal Enigbe,Jennifer Oyakhilome,Edna Omonegho Yerumoh,Ikponmwosa Odia,Chris Aire,Martha Okonofua,Rebecca O Atafo,Ekaete Alice Tobin,Danny Asogun,Nosa Akpede,Peter O. Okokhere,Mojeed Rafiu,Kelly O Iraoyah,Christopher O Iruolagbe,Peter Ehizokhale Akhideno,Cyril Erameh,George O. Akpede,Efosa Isibor,Dhamari Naidoo,Roger Hewson,Julian A. Hiscox,Richard Vipond,Miles W. Carroll,Chikwe Ihekweazu,Pierre Formenty,Sylvanus Okogbenin,Ephraim Ogbaini-Emovon,Stephan Günther,Sophie Duraffour

Outbreak

Lassa fever

Lassa virus

2019

Mobile detection of Lassa virus Lassa fever is a hemorrhagic viral disease endemic to West Africa. Usually, each year sees only a smattering of cases reported, but hospitalized patients risk a 15% chance of death. Responding to fears that a 10-fold surge in cases in Nigeria in 2018 signaled an incipient outbreak, Kafetzopoulou et al. performed metagenomic nanopore sequencing directly from samples from 120 patients (see the Perspective by Bhadelia). Results showed no strong evidence of a new strain emerging nor of person-to-person transmission; rather, rodent contamination was the main source. To prevent future escalation of this disease, we need to understand what triggers the irruption of rodents into human dwellings. Science , this issue p. 74 ; see also p. 30

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“Metagenomic sequencing at the epicenter of the Nigeria 2018 Lassa fever outbreak” is a paper by Liana E. Kafetzopoulou Steven T. Pullan Philippe Lemey Marc A. Suchard Deborah U. Ehichioya Meike Pahlmann Anke Thielebein Julia Hinzmann Lisa Oestereich David M. Wozniak Kyriakos Efthymiadis D Schachten F. O. Koenig J Matjeschk Stephan Lorenzen Sarah Lumley Yemisi Ighodalo Donatus I Adomeh Thomas Olokor Emmanuel Omomoh Racheal Omiunu Jacqueline Agbukor Benevolence Ebo John Aiyepada Paulson Ebhodaghe Osiemi Blessing Solomon Ehikhametalor Patience Akhilomen Michael Airende R Esumeh Ekene Muoebonam Rosemary Giwa Ekanem Anieno Ganiyu Igenegbale George Odigie Grace Okonofua Racheal Enigbe Jennifer Oyakhilome Edna Omonegho Yerumoh Ikponmwosa Odia Chris Aire Martha Okonofua Rebecca O Atafo Ekaete Alice Tobin Danny Asogun Nosa Akpede Peter O. Okokhere Mojeed Rafiu Kelly O Iraoyah Christopher O Iruolagbe Peter Ehizokhale Akhideno Cyril Erameh George O. Akpede Efosa Isibor Dhamari Naidoo Roger Hewson Julian A. Hiscox Richard Vipond Miles W. Carroll Chikwe Ihekweazu Pierre Formenty Sylvanus Okogbenin Ephraim Ogbaini-Emovon Stephan Günther Sophie Duraffour published in 2019. It has an Open Access status of “bronze”. You can read and download a PDF Full Text of this paper here.