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Suppression of TNF-α-Induced Apoptosis by NF-κB

Daniel J. Van Antwerp,Séamus J. Martin,Tal Kafri,Douglas R. Green,Inder M. Verma

Apoptosis

Tumor necrosis factor alpha

Programmed cell death

1996

Tumor necrosis factor alpha (TNF-alpha) signaling gives rise to a number of events, including activation of transcription factor NF-kappaB and programmed cell death (apoptosis). Previous studies of TNF-alpha signaling have suggested that these two events occur independently. The sensitivity and kinetics of TNF-alpha-induced apoptosis are shown to be enhanced in a number of cell types expressing a dominant-negative IkappaBalpha (IkappaBalphaM). These findings suggest that a negative feedback mechanism results from TNF-alpha signaling in which NF-kappaB activation suppresses the signals for cell death.

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“Suppression of TNF-α-Induced Apoptosis by NF-κB” is a paper by Daniel J. Van Antwerp Séamus J. Martin Tal Kafri Douglas R. Green Inder M. Verma published in 1996. It has an Open Access status of “closed”. You can read and download a PDF Full Text of this paper here.