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Neuromuscular Junction in Myasthenia Gravis: Decreased Acetylcholine Receptors

Douglas M. Fambrough,Daniel B. Drachman,Saty Satya‐Murti

Myasthenia gravis

Acetylcholine receptor

Neuromuscular junction

1973

The number of acetylcholine receptors was determined in the neuromuscular junctions of eight patients with typical myasthenia gravis and in five controls, by means of (125)1-labeled alpha-bungarotoxin binding. The junctional acetylcholine receptors were reduced in the myasthenic muscles as compared with the controls. This reduction in receptors may account for the defect in neuromuscular transmission in myasthenia gravis.

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“Neuromuscular Junction in Myasthenia Gravis: Decreased Acetylcholine Receptors” is a paper by Douglas M. Fambrough Daniel B. Drachman Saty Satya‐Murti published in 1973. It has an Open Access status of “closed”. You can read and download a PDF Full Text of this paper here.