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Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak

Stephen K. Gire,Augustine Goba,Kristian G. Andersen,Rachel Sealfon,Daniel J. Park,Lansana Kanneh,Simbirie Jalloh,Mambu Momoh,Mohamed Fullah,Gytis Dudas,Shirlee Wohl,Lina M. Moses,Nathan L. Yozwiak,S Winnicki,Christian B. Matranga,Christine M. Malboeuf,James Qu,Adrianne D. Gladden,Stephen F. Schaffner,Xiao Yang,Panpan Jiang,Mahan Nekoui,Andrés Colubri,Moinya Coomber,Mbalu Fonnie,Alex Moigboi,Michael Gbakie,Fatima K. Kamara,Veronica Tucker,Edwin Konuwa,Sidiki Saffa,Josephine Sellu,Abdul A. Jalloh,Alice Kovoma,James Koninga,Ibrahim Mustapha,Kandeh Kargbo,Momoh Foday,Mohamed Yillah,Franklyn Kanneh,Willie Robert,James L.B. Massally,Sinéad B. Chapman,James Bochicchio,Cheryl I. Murphy,Chad Nusbaum,Sarah Young,Bruce W. Birren,Donald S. Grant,John S. Scheiffelin,Eric S. Lander,Christian T. Happi,Sahr M. Gevao,Andreas Gnirke,Andrew Rambaut,Robert F. Garry,Sheik Humarr Khan,Pardis C. Sabeti

Outbreak

Ebola virus

Ebolavirus

2014

Evolution of Ebola virus over time The high rate of mortality in the current Ebola epidemic has made it difficult for researchers to collect samples of the virus and study its evolution. Gire et al. describe Ebola epidemiology on the basis of 99 whole-genome sequences, including samples from 78 affected individuals. The authors analyzed changes in the viral sequence and conclude that the current outbreak probably resulted from the spread of the virus from central Africa in the past decade. The outbreak started from a single transmission event from an unknown animal reservoir into the human population. Two viral lineages from Guinea then spread from person to person into Sierra Leone. Science , this issue p. 1369

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“Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak” is a paper by Stephen K. Gire Augustine Goba Kristian G. Andersen Rachel Sealfon Daniel J. Park Lansana Kanneh Simbirie Jalloh Mambu Momoh Mohamed Fullah Gytis Dudas Shirlee Wohl Lina M. Moses Nathan L. Yozwiak S Winnicki Christian B. Matranga Christine M. Malboeuf James Qu Adrianne D. Gladden Stephen F. Schaffner Xiao Yang Panpan Jiang Mahan Nekoui Andrés Colubri Moinya Coomber Mbalu Fonnie Alex Moigboi Michael Gbakie Fatima K. Kamara Veronica Tucker Edwin Konuwa Sidiki Saffa Josephine Sellu Abdul A. Jalloh Alice Kovoma James Koninga Ibrahim Mustapha Kandeh Kargbo Momoh Foday Mohamed Yillah Franklyn Kanneh Willie Robert James L.B. Massally Sinéad B. Chapman James Bochicchio Cheryl I. Murphy Chad Nusbaum Sarah Young Bruce W. Birren Donald S. Grant John S. Scheiffelin Eric S. Lander Christian T. Happi Sahr M. Gevao Andreas Gnirke Andrew Rambaut Robert F. Garry Sheik Humarr Khan Pardis C. Sabeti published in 2014. It has an Open Access status of “bronze”. You can read and download a PDF Full Text of this paper here.