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DOI: 10.1126/science.1241224
¤ OpenAccess: Green
This work has “Green” OA status. This means it may cost money to access on the publisher landing page, but there is a free copy in an OA repository.
Sleep Drives Metabolite Clearance from the Adult Brain
Lulu Xie,Hyunmo Kang,Qiwu Xu,Michael Chen,Yonghong Liao,Meenakshisundaram Thiyagarajan,John O’Donnell,Daniel J. Christensen,Charles Nicholson,Jeffrey J. Iliff,Takahiro Takano,Rashid Deane
Glymphatic system
Interstitial fluid
Sleep (system call)
2013
Taking Out the Trash The purpose of sleep remains mysterious. Using state-of-the-art in vivo two-photon imaging to directly compare two arousal states in the same mouse, Xie et al. (p. 373 ; see the Perspective by Herculano-Houzel ) found that metabolic waste products of neural activity were cleared out of the sleeping brain at a faster rate than during the awake state. This finding suggests a mechanistic explanation for how sleep serves a restorative function, in addition to its well-described effects on memory consolidation.
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“Sleep Drives Metabolite Clearance from the Adult Brain” is a paper by Lulu Xie Hyunmo Kang Qiwu Xu Michael Chen Yonghong Liao Meenakshisundaram Thiyagarajan John O’Donnell Daniel J. Christensen Charles Nicholson Jeffrey J. Iliff Takahiro Takano Rashid Deane published in 2013. It has an Open Access status of “green”. You can read and download a PDF Full Text of this paper here.