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DOI: 10.1126/science.1232758
OpenAccess: Closed
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Amplifying Genetic Logic Gates
J. Bonnet,Ping Yin,Monica E. Ortiz,Pakpoom Subsoontorn,Drew Endy
Transistor
Recombinase
Logic gate
2013
Biological Transistor A transistor is a device that amplifies and switches electronic signals. Bonnet et al. (p. 599 , published online 28 March; see the Perspective by Benenson ) engineered a genetic circuit to behave like a transistor in individual living cells. Instead of regulating messenger RNA levels, which has been used previously in designing such systems, the approach relied on changing the state of double-stranded DNA. Six basic logic gates were designed and constructed that were based on the activity of two serine recombinases.
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“Amplifying Genetic Logic Gates” is a paper by J. Bonnet Ping Yin Monica E. Ortiz Pakpoom Subsoontorn Drew Endy published in 2013. It has an Open Access status of “closed”. You can read and download a PDF Full Text of this paper here.