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A Common Variant in the <i>FTO</i> Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

Timothy M. Frayling,Nicholas J. Timpson,Michael N. Weedon,Eleftheria Zeggini,Rachel M. Freathy,Cecilia M. Lindgren,John Perry,Katherine S. Elliott,Hana Lango,Nigel W. Rayner,Beverley M. Shields,Lorna W. Harries,Jeffrey C. Barrett,Sian Ellard,Christopher J. Groves,Bridget Knight,Ann Marie Patch,Andy R Ness,Shah Ebrahim,Debbie A. Lawlor,Susan M. Ring,Yoav Ben-Shlomo,Marjo‐Riitta Järvelin,Ulla Sovio,Amanda J. Bennett,David Melzer,Luigi Ferrucci,Ruth J.F. Loos,Inês Barroso,Nicholas J. Wareham,Fredrik Karpe,Katharine R. Owen,Lon R. Cardon,Mark Walker,G. A. Hitman,Colin N.A. Palmer,Alex S.F. Doney,Andrew D. Morris,George Davey Smith,Andrew T. Hattersley,Mark I. McCarthy

Obesity

Body mass index

Odds ratio

2007

Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetesâsusceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI). An additive association of the variant with BMI was replicated in 13 cohorts with 38,759 participants. The 16% of adults who are homozygous for the risk allele weighed about 3 kilograms more and had 1.67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass.

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“A Common Variant in the <i>FTO</i> Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity” is a paper by Timothy M. Frayling Nicholas J. Timpson Michael N. Weedon Eleftheria Zeggini Rachel M. Freathy Cecilia M. Lindgren John Perry Katherine S. Elliott Hana Lango Nigel W. Rayner Beverley M. Shields Lorna W. Harries Jeffrey C. Barrett Sian Ellard Christopher J. Groves Bridget Knight Ann Marie Patch Andy R Ness Shah Ebrahim Debbie A. Lawlor Susan M. Ring Yoav Ben-Shlomo Marjo‐Riitta Järvelin Ulla Sovio Amanda J. Bennett David Melzer Luigi Ferrucci Ruth J.F. Loos Inês Barroso Nicholas J. Wareham Fredrik Karpe Katharine R. Owen Lon R. Cardon Mark Walker G. A. Hitman Colin N.A. Palmer Alex S.F. Doney Andrew D. Morris George Davey Smith Andrew T. Hattersley Mark I. McCarthy published in 2007. It has an Open Access status of “green”. You can read and download a PDF Full Text of this paper here.