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DOI: 10.1126/science.1131864
OpenAccess: Closed
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Exogenous Induction of Cerebral ß-Amyloidogenesis Is Governed by Agent and Host

Melanie Meyer‐Luehmann,Janaky Coomaraswamy,Tristan Bolmont,Stephan A. Kaeser,Claudia Schaefer,Ellen Kilger,Anton Neuenschwander,Dorothée Abramowski,Peter Frey,Anneliese L. Jaton,J. M. Vigouret,Paolo Paganetti,Dominic M. Walsh,Paul M. Mathews,Jorge Ghiso,Matthias Staufenbiel,Lary C. Walker,Mathias Jucker

Transgene
Amyloid (mycology)
Amyloidosis
2006
Protein aggregation is an established pathogenic mechanism in Alzheimer's disease, but little is known about the initiation of this process in vivo. Intracerebral injection of dilute, amyloid-β (Aβ)–containing brain extracts from humans with Alzheimer's disease or β-amyloid precursor protein (APP) transgenic mice induced cerebral β-amyloidosis and associated pathology in APP transgenic mice in a time- and concentration-dependent manner. The seeding activity of brain extracts was reduced or abolished by Aβ immunodepletion, protein denaturation, or by Aβ immunization of the host. The phenotype of the exogenously induced amyloidosis depended on both the host and the source of the agent, suggesting the existence of polymorphic Aβ strains with varying biological activities reminiscent of prion strains.
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    Exogenous Induction of Cerebral ß-Amyloidogenesis Is Governed by Agent and Host” is a paper by Melanie Meyer‐Luehmann Janaky Coomaraswamy Tristan Bolmont Stephan A. Kaeser Claudia Schaefer Ellen Kilger Anton Neuenschwander Dorothée Abramowski Peter Frey Anneliese L. Jaton J. M. Vigouret Paolo Paganetti Dominic M. Walsh Paul M. Mathews Jorge Ghiso Matthias Staufenbiel Lary C. Walker Mathias Jucker published in 2006. It has an Open Access status of “closed”. You can read and download a PDF Full Text of this paper here.