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Response to Comments on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"

Alan Herbert,Norman P. Gerry,Matthew B. McQueen,Iris M. Heid,Arne Pfeufer,Thomas Illig,H‐Erich Wichmann,Thomas Meitinger,David J. Hunter,Frank B. Hu,Graham A. Colditz,Anke Hinney,Johannes Hebebrand,Kerstin Koberwitz,Xiaofeng Zhu,Richard Cooper,Kristin Ardlie,Helen N. Lyon,Joel N. Hirschhorn,Nan M. Laird,Marc E. Lenburg,Christoph Lange,Michael F. Christman

Obesity

Body mass index

Identification (biology)

2007

Identification of genetic variants affecting complex traits such as obesity is confounded by many types of bias, especially when effect sizes are small. Given our findings of a positive association between rs7566605 and body mass index in four out of five separate samples, a false positive finding cannot be ruled out with certainty but seems unlikely. Meta-analyses of multiple large studies will help refine the estimate of the effects of rs7566605 on body mass index.

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“Response to Comments on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"” is a paper by Alan Herbert Norman P. Gerry Matthew B. McQueen Iris M. Heid Arne Pfeufer Thomas Illig H‐Erich Wichmann Thomas Meitinger David J. Hunter Frank B. Hu Graham A. Colditz Anke Hinney Johannes Hebebrand Kerstin Koberwitz Xiaofeng Zhu Richard Cooper Kristin Ardlie Helen N. Lyon Joel N. Hirschhorn Nan M. Laird Marc E. Lenburg Christoph Lange Michael F. Christman published in 2007. It has an Open Access status of “closed”. You can read and download a PDF Full Text of this paper here.