ϟ
DOI: 10.1126/science.1124779
OpenAccess: Closed
This work is not Open Acccess. We may still have a PDF, if this is the case there will be a green box below.
A Common Genetic Variant Is Associated with Adult and Childhood Obesity
Alan Herbert,Norman P. Gerry,Matthew B. McQueen,Iris M. Heid,Arne Pfeufer,Thomas Illig,H‐Erich Wichmann,Thomas Meitinger,David J. Hunter,Frank B. Hu,Graham A. Colditz,Anke Hinney,Johannes Hebebrand,Kerstin Koberwitz,Xiaofeng Zhu,Richard Cooper,Kristin Ardlie,Helen N. Lyon,Joel N. Hirschhorn,Nan M. Laird,Marc E. Lenburg,Christoph Lange,Michael F. Christman
Obesity
Framingham Heart Study
Type 2 diabetes
2006
Obesity is a heritable trait and a risk factor for many common diseases such as type 2 diabetes, heart disease, and hypertension. We used a dense whole-genome scan of DNA samples from the Framingham Heart Study participants to identify a common genetic variant near the INSIG2 gene associated with obesity. We have replicated the finding in four separate samples composed of individuals of Western European ancestry, African Americans, and children. The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity.
Loading...
- MLA
- APA
- Chicago
- IEEE
- Harvard
- BibTeX
Cite this:
Generate Citation
“A Common Genetic Variant Is Associated with Adult and Childhood Obesity” is a paper by Alan Herbert Norman P. Gerry Matthew B. McQueen Iris M. Heid Arne Pfeufer Thomas Illig H‐Erich Wichmann Thomas Meitinger David J. Hunter Frank B. Hu Graham A. Colditz Anke Hinney Johannes Hebebrand Kerstin Koberwitz Xiaofeng Zhu Richard Cooper Kristin Ardlie Helen N. Lyon Joel N. Hirschhorn Nan M. Laird Marc E. Lenburg Christoph Lange Michael F. Christman published in 2006. It has an Open Access status of “closed”. You can read and download a PDF Full Text of this paper here.