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<i>IL7RA</i> polymorphisms and chronic inflammatory arthropathies

Catherine O’Doherty,Iraide Alloza,Mary Rooney,Koen Vandenbroeck

Single-nucleotide polymorphism

SNP

Medicine

2009

Abstract The C allele of a single nucleotide polymorphism (SNP), rs6897932, located in the interleukin‐7 receptor alpha chain ( IL7RA ) was recently found to be associated with multiple sclerosis and Type I diabetes. We analysed 13 SNPs in the IL7RA gene in a combined cohort of patients with chronic inflammatory arthropathies (rheumatoid arthritis and juvenile idiopathic arthritis; 368 patients and 532 unaffected subjects). No significant associations with disease were found with the exception of the non‐synonymous SNP rs6897932. This SNP showed modest enrichment of the TT genotype in arthritic patients compared with controls [ P = 0.02; OR 1.72 (95% CI 1.08–2.75)]. Our data are suggestive for a role of rs6897932 in predisposition to chronic inflammatory arthropathies.

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“<i>IL7RA</i> polymorphisms and chronic inflammatory arthropathies” is a paper by Catherine O’Doherty Iraide Alloza Mary Rooney Koen Vandenbroeck published in 2009. It has an Open Access status of “closed”. You can read and download a PDF Full Text of this paper here.