ϟ
 
DOI: 10.1111/j.1365-2982.2012.01921.x
¤ OpenAccess: Bronze
This work has “Bronze” OA status. This means it is free to read on the publisher landing page, but without any identifiable license.

Intestinal barrier function in health and gastrointestinal disease

Michael Camilleri,Karen Madsen,Robin C. Spiller,Beverley Greenwood–Van Meerveld,G. Nicholas Verne

Irritable bowel syndrome
Intestinal permeability
Barrier function
2012
Abstract Defects in intestinal barrier function are associated with diseases of the gastrointestinal (GI) tract. There is growing evidence that increases in intestinal permeability plays a pathogenic role in diseases, such as inflammatory bowel disease (IBD) and celiac disease, and functional bowel disorders, such as irritable bowel syndrome (IBS). This review takes a unique translational approach to discuss the physiological and pathophysiological mechanisms involved in the regulation of intestinal barrier function in IBS. The review summarizes the components of the intestinal barrier including the tight junction complex within the epithelium, and the methods used to assess gut permeability both in vitro and in vivo . Throughout the review, the authors have attempted to critically review the latest research from both experimental animal models and human studies to appraise whether intestinal barrier dysfunction is a primary cause of functional GI disorders, such as IBS.…
Loading...
    Cite this:
Generate Citation
Powered by Citationsy*
    Intestinal barrier function in health and gastrointestinal disease” is a paper by Michael Camilleri Karen Madsen Robin C. Spiller Beverley Greenwood–Van Meerveld G. Nicholas Verne published in 2012. It has an Open Access status of “bronze”. You can read and download a PDF Full Text of this paper here.