DOI: 10.1093/jnci/djt123

¤ OpenAccess: Bronze

This work has “Bronze” OA status. This means it is free to read on the publisher landing page, but without any identifiable license.

Hyperglycemia, Insulin Resistance, Impaired Pancreatic β-Cell Function, and Risk of Pancreatic Cancer

Brian M. Wolpin,Ying Bao,Zhi Rong Qian,Chaochao Wu,Peter Kraft,Shuji Ogino,Meir J. Stampfer,Kaori Sato,Jing Ma,Julie E. Buring,Howard D. Sesso,I-Min Lee,J. Michael Gaziano,Anne McTiernan,Lawrence Phillips,Barbara B. Cochrane,Michael Pollak,JoAnn E. Manson,Edward Giovannucci,Charles S. Fuchs

Proinsulin

Insulin resistance

Internal medicine

2013

BackgroundObesity and diabetes mellitus are associated with an increased risk of pancreatic cancer. These associations may be secondary to consequences of peripheral insulin resistance, pancreatic β-cell dysfunction, or hyperglycemia itself. Hemoglobin A1c (HbA1c) is a measure of hyperglycemia, whereas plasma insulin and proinsulin are markers of peripheral insulin resistance, and the proinsulin to insulin ratio marks pancreatic β-cell dysfunction.

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“Hyperglycemia, Insulin Resistance, Impaired Pancreatic β-Cell Function, and Risk of Pancreatic Cancer” is a paper by Brian M. Wolpin Ying Bao Zhi Rong Qian Chaochao Wu Peter Kraft Shuji Ogino Meir J. Stampfer Kaori Sato Jing Ma Julie E. Buring Howard D. Sesso I-Min Lee J. Michael Gaziano Anne McTiernan Lawrence Phillips Barbara B. Cochrane Michael Pollak JoAnn E. Manson Edward Giovannucci Charles S. Fuchs published in 2013. It has an Open Access status of “bronze”. You can read and download a PDF Full Text of this paper here.