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DOI: 10.1084/jem.20060772
¤ OpenAccess: Bronze
This work has “Bronze” OA status. This means it is free to read on the publisher landing page, but without any identifiable license.

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

Weihong Liu,Amy Putnam,Xuyu Zhou,Gregory L. Szot,Michael R. F. Lee,Shaowei Zhu,Peter Gottlieb,Philipp Kapranov,T Gingeras,Barbara Fazekas de St Groth,Carol Clayberger,David Soper,Steven F. Ziegler,Jeffrey A. Bluestone

Interleukin-7 receptor
IL-2 receptor
FOXP3
2006
Regulatory T (T reg) cells are critical regulators of immune tolerance. Most T reg cells are defined based on expression of CD4, CD25, and the transcription factor, FoxP3. However, these markers have proven problematic for uniquely defining this specialized T cell subset in humans. We found that the IL-7 receptor (CD127) is down-regulated on a subset of CD4(+) T cells in peripheral blood. We demonstrate that the majority of these cells are FoxP3(+), including those that express low levels or no CD25. A combination of CD4, CD25, and CD127 resulted in a highly purified population of T reg cells accounting for significantly more cells that previously identified based on other cell surface markers. These cells were highly suppressive in functional suppressor assays. In fact, cells separated based solely on CD4 and CD127 expression were anergic and, although representing at least three times the number of cells (including both CD25(+)CD4(+) and CD25(-)CD4(+) T cell subsets), were as suppressive as the "classic" CD4(+)CD25(hi) T reg cell subset. Finally, we show that CD127 can be used to quantitate T reg cell subsets in individuals with type 1 diabetes supporting the use of CD127 as a biomarker for human T reg cells.
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    CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells” is a paper by Weihong Liu Amy Putnam Xuyu Zhou Gregory L. Szot Michael R. F. Lee Shaowei Zhu Peter Gottlieb Philipp Kapranov T Gingeras Barbara Fazekas de St Groth Carol Clayberger David Soper Steven F. Ziegler Jeffrey A. Bluestone published in 2006. It has an Open Access status of “bronze”. You can read and download a PDF Full Text of this paper here.