¤ OpenAccess: Bronze

This work has “Bronze” OA status. This means it is free to read on the publisher landing page, but without any identifiable license.

Toxicity, pharmacokinetics, and <i>in vivo</i> efficacy of biotinylated chitosan surface-modified PLGA nanoparticles for tumor therapy

Hongli Chen,Wenbin Nan,Xiangjuan Wei,Yan Wang,Feng Lv,Huiping Tang,Yonghai Li,Chenyan Zhou,Juntang Lin,Wuling Zhu,Qiqing Zhang

PLGA

Pharmacokinetics

Toxicity

2016

Based on our previous work on the PLGA nanoparticles modified with biotinylated chitosan (Bio-CS-PLGA NPs), we further studied the stability, toxicity, pharmacokinetics, and in vivo efficacy. The safety of NPs was studied through single-dose toxicity test in mice, and the result showed that NPs were well tolerated at the dose of 300 mg/kg. Compared with the free EPB group, the NPs group exhibited higher plasma drug concentration, longer half-life time. EPB-loaded NPs significantly inhibited the tumor growth compared to free EPB. All results suggested that Bio-CS-PLGA NPs were stable, safe, and showed a promising potential on targeted drug delivery.

Cite this:

Generate Citation

“Toxicity, pharmacokinetics, and <i>in vivo</i> efficacy of biotinylated chitosan surface-modified PLGA nanoparticles for tumor therapy” is a paper by Hongli Chen Wenbin Nan Xiangjuan Wei Yan Wang Feng Lv Huiping Tang Yonghai Li Chenyan Zhou Juntang Lin Wuling Zhu Qiqing Zhang published in 2016. It has an Open Access status of “bronze”. You can read and download a PDF Full Text of this paper here.