ϟ
 
DOI: 10.1080/10717544.2018.1428245
¤ OpenAccess: Gold
This work has “Gold” OA status. This means it is published in an Open Access journal that is indexed by the DOAJ.

HSA-based multi-target combination therapy: regulating drugs’ release from HSA and overcoming single drug resistance in a breast cancer model

Yanzi Gou,Zhenlei Zhang,Dongyang Li,Lei Zhao,Meiling Cai,Zhaohui Sun,Yongping Li,Yao Zhang,Hina Khan,Hongbing Sun,Tao Wang,Hong Liang,Feng Yang

Human serum albumin
In vivo
Doxorubicin
2018
Multi-drug delivery systems, which may be promising solution to overcome obstacles, have limited the clinical success of multi-drug combination therapies to treat cancer. To this end, we used three different anticancer agents, Cu(BpT)Br, NAMI-A, and doxorubicin (DOX), to build human serum albumin (HSA)-based multi-drug delivery systems in a breast cancer model to investigate the therapeutic efficacy of overcoming single drug (DOX) resistance to cancer cells in vivo, and to regulate the drugs' release from HSA. The HSA complex structure revealed that NAMI-A and Cu(BpT)Br bind to the IB and IIA sub-domain of HSA by N-donor residue replacing a leaving group and coordinating to their metal centers, respectively. The MALDI-TOF mass spectra demonstrated that one DOX molecule is conjugated with lysine of HSA by a pH-sensitive linker. Furthermore, the release behavior of three agents form HSA can be regulated at different pH levels. Importantly, in vivo results revealed that the HSA-NAMI-A-Cu(BpT)Br-DOX complex not only increases the targeting ability compared with a combination of the three agents (the NAMI-A/Cu(BpT)Br/DOX mixture), but it also overcomes DOX resistance to drug-resistant breast cancer cell lines.
Loading...
    Cite this:
Generate Citation
Powered by Citationsy*
    HSA-based multi-target combination therapy: regulating drugs’ release from HSA and overcoming single drug resistance in a breast cancer model” is a paper by Yanzi Gou Zhenlei Zhang Dongyang Li Lei Zhao Meiling Cai Zhaohui Sun Yongping Li Yao Zhang Hina Khan Hongbing Sun Tao Wang Hong Liang Feng Yang published in 2018. It has an Open Access status of “gold”. You can read and download a PDF Full Text of this paper here.