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Mitochondria are selective targets for the protective effects of heat shock against oxidative injury.

Barbara S. Polla,Salomé Kantengwa,Dominique François,Stefano Salvioli,Claudio Franceschi,Cécile Marsac,Andrea Cossarizza

Mitochondrion

Reactive oxygen species

Heat shock protein

1996

Heat shock (HS) proteins (HSPs) induce protection against a number of stresses distinct from HS, including reactive oxygen species. In the human premonocytic line U937, we investigated in whole cells the effects of preexposure to HS and exposure to hydrogen peroxide (H2O2) on mitochondrial membrane potential, mass, and ultrastructure. HS prevented H2O2-induced alterations in mitochondrial membrane potential and cristae formation while increasing expression of HSPs and the protein product of bcl-2. Protection correlated best with the expression of the 70-kDa HSP, hsp70. We propose that mitochondria represent a selective target for HS-mediated protection against oxidative injury.

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“Mitochondria are selective targets for the protective effects of heat shock against oxidative injury.” is a paper by Barbara S. Polla Salomé Kantengwa Dominique François Stefano Salvioli Claudio Franceschi Cécile Marsac Andrea Cossarizza published in 1996. It has an Open Access status of “green”. You can read and download a PDF Full Text of this paper here.