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Characterization of immune responses following intramuscular DNA immunization with the MOMP gene of <i>Chlamydia trachomatis</i> mouse pneumonitis strain

D J Zhang,Xi Yang,Caixia Shen,Robert C. Brunham

Immune system

Biology

Chlamydia trachomatis

1999

Studies were carried out to characterize the cellular and humoral immune responses evoked by intramuscular DNA vaccination with the major outer membrane protein (MOMP) gene of Chlamydia trachomatis mouse pneumonitis strain. The data demonstrate that DNA vaccinated mice develop antigen-specific delayed-type hypersensitivity, lymphocyte proliferation and interferon-gamma (IFN-gamma) production. Serum antibody responses (mainly immunoglobulin G2a; IgG2a) were evoked in two-thirds of the mice. We conclude that intramuscular DNA immunization with the MOMP gene evokes cellular and humoral immune responses suggestive of a T helper 1 (Th1) bias.

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“Characterization of immune responses following intramuscular DNA immunization with the MOMP gene of <i>Chlamydia trachomatis</i> mouse pneumonitis strain” is a paper by D J Zhang Xi Yang Caixia Shen Robert C. Brunham published in 1999. It has an Open Access status of “bronze”. You can read and download a PDF Full Text of this paper here.