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SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

Waradon Sungnak,Ni Huang,Christophe Bécavin,Marijn Berg,Rachel Queen,Monika Litviňuková,Carlos Talavera‐López,Henrike Maatz,Daniel Reichart,Fotios Sampaziotis,Kaylee B. Worlock,Masahiro Yoshida,Josephine Barnes

Innate immune system

Tropism

Biology

2020

We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells' potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.

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“SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes” is a paper by Waradon Sungnak Ni Huang Christophe Bécavin Marijn Berg Rachel Queen Monika Litviňuková Carlos Talavera‐López Henrike Maatz Daniel Reichart Fotios Sampaziotis Kaylee B. Worlock Masahiro Yoshida Josephine Barnes published in 2020. It has an Open Access status of “bronze”. You can read and download a PDF Full Text of this paper here.