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DOI: 10.1038/nrg2484
¤ OpenAccess: Green
This work has “Green” OA status. This means it may cost money to access on the publisher landing page, but there is a free copy in an OA repository.
RNA-Seq: a revolutionary tool for transcriptomics
Zhong Wang,Mark Gerstein,M Snyder
RNA-Seq
Biology
Transcriptome
2009
The development of high-throughput DNA sequencing methods provides a new method for mapping and quantifying transcriptomes — RNA sequencing (RNA-Seq). This article explains how RNA-Seq works, the challenges it faces and how it is changing our view of eukaryotic transcriptomes. RNA-Seq is a recently developed approach to transcriptome profiling that uses deep-sequencing technologies. Studies using this method have already altered our view of the extent and complexity of eukaryotic transcriptomes. RNA-Seq also provides a far more precise measurement of levels of transcripts and their isoforms than other methods. This article describes the RNA-Seq approach, the challenges associated with its application, and the advances made so far in characterizing several eukaryote transcriptomes.
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“RNA-Seq: a revolutionary tool for transcriptomics” is a paper by Zhong Wang Mark Gerstein M Snyder published in 2009. It has an Open Access status of “green”. You can read and download a PDF Full Text of this paper here.