DOI: 10.1038/nm.3932

¤ OpenAccess: Green

This work has “Green” OA status. This means it may cost money to access on the publisher landing page, but there is a free copy in an OA repository.

HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders

Holly Janes,Joshua T. Herbeck,Sodsai Tovanabutra,Rasmi Thomas,Nicole Frahm,Ann Duerr,John Hural,Lawrence Corey,Steve Self,Susan Buchbinder,M. Juliana McElrath,Robert J. O’Connell,Robert Paris,Supachai Rerks-Ngarm,Sorachai Nitayaphan,Punnee Pitisuttihum,Jaranit Kaewkungwal,Merlin L. Robb,Nelson L. Michael,James I. Mullins,Jerome H. Kim,Peter B. Gilbert,Morgane Rolland

Viral load

Human immunodeficiency virus (HIV)

Virology

2015

Given the variation in the HIV-1 viral load (VL) set point across subjects, as opposed to a fairly stable VL over time within an infected individual, it is important to identify the characteristics of the host and virus that affect VL set point. Although recently infected individuals with multiple phylogenetically linked HIV-1 founder variants represent a minority of HIV-1 infections, we found--n two different cohorts--hat more diverse HIV-1 populations in early infection were associated with significantly higher VL 1 year after HIV-1 diagnosis.

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“HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders” is a paper by Holly Janes Joshua T. Herbeck Sodsai Tovanabutra Rasmi Thomas Nicole Frahm Ann Duerr John Hural Lawrence Corey Steve Self Susan Buchbinder M. Juliana McElrath Robert J. O’Connell Robert Paris Supachai Rerks-Ngarm Sorachai Nitayaphan Punnee Pitisuttihum Jaranit Kaewkungwal Merlin L. Robb Nelson L. Michael James I. Mullins Jerome H. Kim Peter B. Gilbert Morgane Rolland published in 2015. It has an Open Access status of “green”. You can read and download a PDF Full Text of this paper here.