DOI: 10.1038/ng.522

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A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33

Gloria M. Petersen,Laufey T. Ámundadóttir,Charles S. Fuchs,Peter Kraft,Rachael Z. Stolzenberg‐Solomon,Kevin B. Jacobs,Alan A. Arslan,H. Bas Bueno-De-Mesquita,Steven Gallinger,Myron Gross,Kathy J. Helzlsouer,Elizabeth A. Holly,Eric J. Jacobs,Alison P. Klein,Andrea Z. LaCroix,Donghui Li,Margaret T. Mandelson,Sara H. Olson,Harvey A. Risch,Zheng Wang,Demetrius Albanês,William R. Bamlet,Christine D. Berg,Marie Christine Boutron-Ruault,Julie E. Buring,Paige M. Bracci,Federico Canzian,Sandra Clipp,Michelle Cotterchio,Mariza de Andrade,Eric J. Duell,J. Michael Gaziano,Edward Giovannucci,Michael Goggins,Göran Hallmans,Susan E. Hankinson,Manal M. Hassan,Barbara V. Howard,David J. Hunter,Amy Hutchinson,Mazda Jenab,Rudolf Kaaks,Charles Kooperberg,Vittorio Krogh,Robert C. Kurtz,Shannon M. Lynch,Robert R. McWilliams,Julie B. Mendelsohn,Dominique S. Michaud,Hemang Parikh,Alpa V. Patel,Petra H.M. Peeters,Aleksandar Rajkovic,Elio Ríboli,Laudina Rodríguez,Daniela Seminara,Xiao Ou Shu,Gilles Thomas,Anne Tjønneland,Geoffrey S. Tobias,Dimitrios Trichopoulos,Stephen K. Van Den Eeden,Jarmo Virtamo,Jean Wactawski‐Wende,Zhaoming Wang,Brian M. Wolpin,Herbert Yu,Kai Yu,Anne Zeleniuch‐Jacquotte,Joseph F. Fraumeni,Robert N. Hoover,Patricia Hartge,Stephen J. Chanock

Single-nucleotide polymorphism

Biology

Locus (genetics)

2010

We conducted a genome-wide association study of pancreatic cancer in 3,851 affected individuals (cases) and 3,934 unaffected controls drawn from 12 prospective cohort studies and 8 case-control studies. Based on a logistic regression model for genotype trend effect that was adjusted for study, age, sex, self-described ancestry and five principal components, we identified eight SNPs that map to three loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Two correlated SNPs, rs9543325 (P = 3.27 x 10(-11), per-allele odds ratio (OR) 1.26, 95% CI 1.18-1.35) and rs9564966 (P = 5.86 x 10(-8), per-allele OR 1.21, 95% CI 1.13-1.30), map to a nongenic region on chromosome 13q22.1. Five SNPs on 1q32.1 map to NR5A2, and the strongest signal was at rs3790844 (P = 2.45 x 10(-10), per-allele OR 0.77, 95% CI 0.71-0.84). A single SNP, rs401681 (P = 3.66 x 10(-7), per-allele OR 1.19, 95% CI 1.11-1.27), maps to the CLPTM1L-TERT locus on 5p15.33, which is associated with multiple cancers. Our study has identified common susceptibility loci for pancreatic cancer that warrant follow-up studies.

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“A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33” is a paper by Gloria M. Petersen Laufey T. Ámundadóttir Charles S. Fuchs Peter Kraft Rachael Z. Stolzenberg‐Solomon Kevin B. Jacobs Alan A. Arslan H. Bas Bueno-De-Mesquita Steven Gallinger Myron Gross Kathy J. Helzlsouer Elizabeth A. Holly Eric J. Jacobs Alison P. Klein Andrea Z. LaCroix Donghui Li Margaret T. Mandelson Sara H. Olson Harvey A. Risch Zheng Wang Demetrius Albanês William R. Bamlet Christine D. Berg Marie Christine Boutron-Ruault Julie E. Buring Paige M. Bracci Federico Canzian Sandra Clipp Michelle Cotterchio Mariza de Andrade Eric J. Duell J. Michael Gaziano Edward Giovannucci Michael Goggins Göran Hallmans Susan E. Hankinson Manal M. Hassan Barbara V. Howard David J. Hunter Amy Hutchinson Mazda Jenab Rudolf Kaaks Charles Kooperberg Vittorio Krogh Robert C. Kurtz Shannon M. Lynch Robert R. McWilliams Julie B. Mendelsohn Dominique S. Michaud Hemang Parikh Alpa V. Patel Petra H.M. Peeters Aleksandar Rajkovic Elio Ríboli Laudina Rodríguez Daniela Seminara Xiao Ou Shu Gilles Thomas Anne Tjønneland Geoffrey S. Tobias Dimitrios Trichopoulos Stephen K. Van Den Eeden Jarmo Virtamo Jean Wactawski‐Wende Zhaoming Wang Brian M. Wolpin Herbert Yu Kai Yu Anne Zeleniuch‐Jacquotte Joseph F. Fraumeni Robert N. Hoover Patricia Hartge Stephen J. Chanock published in 2010. It has an Open Access status of “green”. You can read and download a PDF Full Text of this paper here.