ϟ
DOI: 10.1038/ng.3738
¤ OpenAccess: Green
This work has “Green” OA status. This means it may cost money to access on the publisher landing page, but there is a free copy in an OA repository.
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation
Audrey Y. Chu,Xuan Deng,Virginia Fisher,Alexander Drong,Yang Zhang,Mary F. Feitosa,Ching‐Ti Liu,Olivia Weeks,Audrey C. Choh,Qing Duan,Thomas D. Dyer,John D. Eicher,Xiuqing Guo,Nancy L. Heard‐Costa,Tim Kacprowski,Jack W. Kent,Leslie A. Lange,Xinggang Liu,Kurt Lohman,Lingyi Lu,Anubha Mahajan,Jeffrey R. O’Connell,Ankita Parihar,Juan M. Peralta,Albert V. Smith,Yi Zhang,Georg Homuth,Ahmed H. Kissebah,Joel Kullberg,René Laqua,Lenore J. Launer,Matthias Nauck,Michael Olivier,Patricia A. Peyser,James G. Terry,Mary K. Wojczynski,Jie Yao,Lawrence F. Bielak,John Blangero,Ingrid B. Borecki,Donald W. Bowden,J. Jeffrey Carr,Stefan A. Czerwinski,Jingzhong Ding,Nele Friedrich,Vilmundur Gudnason,Tamara B. Harris,Erik Ingelsson,Andrew D. Johnson,Sharon L. R. Kardia,Carl D. Langefeld,Lars Lind,Yongmei Liu,Braxton D. Mitchell,Andrew P. Morris,Thomas H. Mosley,Jerome I. Rotter,Alan R. Shuldiner,Bradford Towne,Henry Völzke,Henri Wallaschofski,James G. Wilson,Matthew A. Allison,Cecilia M. Lindgren,Wolfram Goessling,L. Adrienne Cupples,Matthew L. Steinhauser,Caroline S. Fox
Biology
Adipocyte
Obesity
2016
Variation in body fat distribution contributes to the metabolic sequelae of obesity. The genetic determinants of body fat distribution are poorly understood. The goal of this study was to gain new insights into the underlying genetics of body fat distribution by conducting sample-size-weighted fixed-effects genome-wide association meta-analyses in up to 9,594 women and 8,738 men of European, African, Hispanic and Chinese ancestry, with and without sex stratification, for six traits associated with ectopic fat (hereinafter referred to as ectopic-fat traits). In total, we identified seven new loci associated with ectopic-fat traits (ATXN1, UBE2E2, EBF1, RREB1, GSDMB, GRAMD3 and ENSA; P < 5 × 10-8; false discovery rate < 1%). Functional analysis of these genes showed that loss of function of either Atxn1 or Ube2e2 in primary mouse adipose progenitor cells impaired adipocyte differentiation, suggesting physiological roles for ATXN1 and UBE2E2 in adipogenesis. Future studies are necessary to further explore the mechanisms by which these genes affect adipocyte biology and how their perturbations contribute to systemic metabolic disease.
Loading...
- MLA
- APA
- Chicago
- IEEE
- Harvard
- BibTeX
Cite this:
Generate Citation
“Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation” is a paper by Audrey Y. Chu Xuan Deng Virginia Fisher Alexander Drong Yang Zhang Mary F. Feitosa Ching‐Ti Liu Olivia Weeks Audrey C. Choh Qing Duan Thomas D. Dyer John D. Eicher Xiuqing Guo Nancy L. Heard‐Costa Tim Kacprowski Jack W. Kent Leslie A. Lange Xinggang Liu Kurt Lohman Lingyi Lu Anubha Mahajan Jeffrey R. O’Connell Ankita Parihar Juan M. Peralta Albert V. Smith Yi Zhang Georg Homuth Ahmed H. Kissebah Joel Kullberg René Laqua Lenore J. Launer Matthias Nauck Michael Olivier Patricia A. Peyser James G. Terry Mary K. Wojczynski Jie Yao Lawrence F. Bielak John Blangero Ingrid B. Borecki Donald W. Bowden J. Jeffrey Carr Stefan A. Czerwinski Jingzhong Ding Nele Friedrich Vilmundur Gudnason Tamara B. Harris Erik Ingelsson Andrew D. Johnson Sharon L. R. Kardia Carl D. Langefeld Lars Lind Yongmei Liu Braxton D. Mitchell Andrew P. Morris Thomas H. Mosley Jerome I. Rotter Alan R. Shuldiner Bradford Towne Henry Völzke Henri Wallaschofski James G. Wilson Matthew A. Allison Cecilia M. Lindgren Wolfram Goessling L. Adrienne Cupples Matthew L. Steinhauser Caroline S. Fox published in 2016. It has an Open Access status of “green”. You can read and download a PDF Full Text of this paper here.