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DOI: 10.1038/ng.2797
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Discovery and refinement of loci associated with lipid levels
Cristen J. Willer,Ellen M. Schmidt,Sebanti Sengupta,Gina M. Peloso,Stefan Gustafsson,Stavroula Kanoni,Andrea Ganna,Jin Chen,Martin L. Buchkovich,Samia Mora,Jacques S. Beckmann,Jennifer L. Bragg‐Gresham,Hsing Yi Chang,Ayşe Demirkan,Heleen M. den Hertog,Ron Do,Louise A. Donnelly,Georg Ehret,Tõnu Esko,Mary F. Feitosa,Teresa Ferreira,Krista Fischer,Pierre Fontanillas,Ross M. Fraser,Daniel F. Freitag,Deepti Gurdasani,Kauko Heikkilä,Elina Hyppönen,Aaron Isaacs,Anne Jackson,Åsa Johansson,Toby Johnson,Marika Kaakinen,Johannes Kettunen,Marcus E. Kleber,Xiaohui Li,Jian’an Luan,Leo‐Pekka Lyytikäinen,Patrik K. E. Magnusson,Massimo Mangino,Evelin Mihailov,May E. Montasser,Martina Müller‐Nurasyid,Ilja M. Nolte,Jeffrey R. O’Connell,Cameron D. Palmer,Markus Perola,Ann Kristin Petersen,Serena Sanna,Richa Saxena,Sonia Shah,Dmitry Shungin,Carlo Sidore,Ci Song,Rona J. Strawbridge,Ida Surakka,Toshiko Tanaka,Tanya M. Teslovich,Guðmar Þorleifsson,Evita G. van den Herik,Benjamin F. Voight,Kelly A. Volcik,Lindsay L. Waite,Andrew Wong,Ying Wu,Weihua Zhang,Devin Absher,Gershim Asiki,Inês Barroso,Latonya Been,Jennifer L. Bolton,Lori L. Bonnycastle,Paolo Brambilla,Mary Susan Burnett,Giancarlo Cesana,Maria Dimitriou,Alex S.F. Doney,Angela Döring,Paul Elliott,Stephen E. Epstein,Gudmundur I. Eyjolfsson,Bruna Gigante,Mark O. Goodarzi,Harald Grallert,Martha L. Gravito,Christopher J. Groves,Göran Hallmans,Anna Liisa Hartikainen,Caroline Hayward,Dena G. Hernandez,Andrew A. Hicks,Hilma Hólm,Yi Jen Hung,Thomas Illig,Lindsay Waite Jones,Pontiano Kaleebu,John J.P. Kastelein,Kay Tee Khaw,Eric Kim,Norman Klopp,Pirjo Komulainen,Meena Kumari,Claudia Langenberg,Terho Lehtimäki,Shih Yi Lin,Jaana Lindström,Ruth J.F. Loos,François Mach,Wendy L. McArdle,Christa Meisinger,Braxton D. Mitchell,Gabrielle Müller,Ramaiah Nagaraja,Narisu Narisu,Tuomo Nieminen,Rebecca N. Nsubuga,Ísleifur Ólafsson,Ken K. Ong,Aarno Palotie,Theodore Papamarkou,Cristina Pomilla,Anneli Pouta,Daniel J. Rader,Muredach P. Reilly,Paul M. Ridker,Fernando Rivadeneira,Igor Rudan,Aimo Ruokonen,Nilesh J. Samani,Hubert Scharnagl,Janet Seeley,Kaisa Silander,Alena Stančáková,Kathleen Stirrups,Amy J. Swift,Laurence Tiret,André G. Uitterlinden,L. Joost van Pelt,Sailaja Vedantam,Nicholas W.J. Wainwright,Cisca Wijmenga,Sarah H. Wild,Gonneke Willemsen,Tom Wilsgaard,James F. Wilson,Elizabeth Young,Jing Hua Zhao,Linda S. Adair,Dominique Arveiler,Themistocles L. Assimes,Stefania Bandinelli,Franklyn I. Bennett,Murielle Bochud,Bernhard O. Boehm,Dorret I. Boomsma,Ingrid B. Borecki,Stefan R. Bornstein,Pascal Bovet,Michel Burnier,Harry Campbell,Aravinda Chakravarti,John C. Chambers,Yii Der Ida Chen,Francis S. Collins,Richard S. Cooper,John Danesh,George Dedoussis,Ulf dé Fairé,Alan B. Feranil,Jean Ferrières,Luigi Ferrucci,Nelson B. Freimer,Christian Gieger,Leif Groop,Vilmundur Gudnason,Ulf Gyllensten,Anders Hamsten,Tamara B. Harris,Aroon D. Hingorani,Joel N. Hirschhorn,Albert Hofman,G. Kees Hovingh,Chao A. Hsiung,Steve E. Humphries,Steven C. Hunt,Kristian Hveem,Carlos Iribarren,Marjo Riitta Järvelin,Antti Jula,Mika Kähönen,Jaakko Kaprio,Antero Kesäniemi,Mika Kivimäki,Jaspal S. Kooner,Peter J. Koudstaal,Ronald M. Krauss,Diana Kuh,Johanna Kuusisto,Kirsten Ohm Kyvik,Markku Laakso,Timo A. Lakka,Lars Lind,Cecilia M. Lindgren,Nicholas G. Martin,Winfried März,Mark I. McCarthy,Colin A. McKenzie,Pierre Meneton,Andres Metspalu,Leena Moilanen,Andrew D. Morris,Patricia B. Munroe,Inger Njølstad,Nancy L. Pedersen,Chris Power,Peter P. Pramstaller,Jackie F. Price,Bruce M. Psaty,Thomas Quertermous,Rainer Rauramaa,Danish Saleheen,Veikko Salomaa,Dharambir K. Sanghera,Jouko Saramies,Peter E. H. Schwarz,Wayne H.-H. Sheu,Alan R. Shuldiner,Agneta Siegbahn,Tim D. Spector,Kári Stefansson,David P. Strachan,Bamidele O. Tayo,Elena Tremoli,Jaakko Tuomilehto,Matti Uusitupa,Cornelia M. van Duijn,Péter Vollenweider,Lars Wallentin,Nicholas J. Wareham,John B. Whitfield,Bruce H. R. Wolffenbuttel,José M. Ordovás,Eric Boerwinkle,Colin N. A. Palmer,Unnur Þorsteinsdóttir,Daniel I. Chasman,Jerome I. Rotter,Paul W. Franks,Samuli Ripatti,L. Adrienne Cupples,Manjinder S. Sandhu,Stephen S. Rich,Michael Boehnke,Panos Deloukas,Sekar Kathiresan,Karen L. Mohlke,Erik Ingelsson,Gonçalo R. Abecasis
Biology
Computational biology
Genetics
2013
Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 × 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.
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“Discovery and refinement of loci associated with lipid levels” is a paper by Cristen J. Willer Ellen M. Schmidt Sebanti Sengupta Gina M. Peloso Stefan Gustafsson Stavroula Kanoni Andrea Ganna Jin Chen Martin L. Buchkovich Samia Mora Jacques S. Beckmann Jennifer L. Bragg‐Gresham Hsing Yi Chang Ayşe Demirkan Heleen M. den Hertog Ron Do Louise A. Donnelly Georg Ehret Tõnu Esko Mary F. Feitosa Teresa Ferreira Krista Fischer Pierre Fontanillas Ross M. Fraser Daniel F. Freitag Deepti Gurdasani Kauko Heikkilä Elina Hyppönen Aaron Isaacs Anne Jackson Åsa Johansson Toby Johnson Marika Kaakinen Johannes Kettunen Marcus E. Kleber Xiaohui Li Jian’an Luan Leo‐Pekka Lyytikäinen Patrik K. E. Magnusson Massimo Mangino Evelin Mihailov May E. Montasser Martina Müller‐Nurasyid Ilja M. Nolte Jeffrey R. O’Connell Cameron D. Palmer Markus Perola Ann Kristin Petersen Serena Sanna Richa Saxena Sonia Shah Dmitry Shungin Carlo Sidore Ci Song Rona J. Strawbridge Ida Surakka Toshiko Tanaka Tanya M. Teslovich Guðmar Þorleifsson Evita G. van den Herik Benjamin F. Voight Kelly A. Volcik Lindsay L. Waite Andrew Wong Ying Wu Weihua Zhang Devin Absher Gershim Asiki Inês Barroso Latonya Been Jennifer L. Bolton Lori L. Bonnycastle Paolo Brambilla Mary Susan Burnett Giancarlo Cesana Maria Dimitriou Alex S.F. Doney Angela Döring Paul Elliott Stephen E. Epstein Gudmundur I. Eyjolfsson Bruna Gigante Mark O. Goodarzi Harald Grallert Martha L. Gravito Christopher J. Groves Göran Hallmans Anna Liisa Hartikainen Caroline Hayward Dena G. Hernandez Andrew A. Hicks Hilma Hólm Yi Jen Hung Thomas Illig Lindsay Waite Jones Pontiano Kaleebu John J.P. Kastelein Kay Tee Khaw Eric Kim Norman Klopp Pirjo Komulainen Meena Kumari Claudia Langenberg Terho Lehtimäki Shih Yi Lin Jaana Lindström Ruth J.F. Loos François Mach Wendy L. McArdle Christa Meisinger Braxton D. Mitchell Gabrielle Müller Ramaiah Nagaraja Narisu Narisu Tuomo Nieminen Rebecca N. Nsubuga Ísleifur Ólafsson Ken K. Ong Aarno Palotie Theodore Papamarkou Cristina Pomilla Anneli Pouta Daniel J. Rader Muredach P. Reilly Paul M. Ridker Fernando Rivadeneira Igor Rudan Aimo Ruokonen Nilesh J. Samani Hubert Scharnagl Janet Seeley Kaisa Silander Alena Stančáková Kathleen Stirrups Amy J. Swift Laurence Tiret André G. Uitterlinden L. Joost van Pelt Sailaja Vedantam Nicholas W.J. Wainwright Cisca Wijmenga Sarah H. Wild Gonneke Willemsen Tom Wilsgaard James F. Wilson Elizabeth Young Jing Hua Zhao Linda S. Adair Dominique Arveiler Themistocles L. Assimes Stefania Bandinelli Franklyn I. Bennett Murielle Bochud Bernhard O. Boehm Dorret I. Boomsma Ingrid B. Borecki Stefan R. Bornstein Pascal Bovet Michel Burnier Harry Campbell Aravinda Chakravarti John C. Chambers Yii Der Ida Chen Francis S. Collins Richard S. Cooper John Danesh George Dedoussis Ulf dé Fairé Alan B. Feranil Jean Ferrières Luigi Ferrucci Nelson B. Freimer Christian Gieger Leif Groop Vilmundur Gudnason Ulf Gyllensten Anders Hamsten Tamara B. Harris Aroon D. Hingorani Joel N. Hirschhorn Albert Hofman G. Kees Hovingh Chao A. Hsiung Steve E. Humphries Steven C. Hunt Kristian Hveem Carlos Iribarren Marjo Riitta Järvelin Antti Jula Mika Kähönen Jaakko Kaprio Antero Kesäniemi Mika Kivimäki Jaspal S. Kooner Peter J. Koudstaal Ronald M. Krauss Diana Kuh Johanna Kuusisto Kirsten Ohm Kyvik Markku Laakso Timo A. Lakka Lars Lind Cecilia M. Lindgren Nicholas G. Martin Winfried März Mark I. McCarthy Colin A. McKenzie Pierre Meneton Andres Metspalu Leena Moilanen Andrew D. Morris Patricia B. Munroe Inger Njølstad Nancy L. Pedersen Chris Power Peter P. Pramstaller Jackie F. Price Bruce M. Psaty Thomas Quertermous Rainer Rauramaa Danish Saleheen Veikko Salomaa Dharambir K. Sanghera Jouko Saramies Peter E. H. Schwarz Wayne H.-H. Sheu Alan R. Shuldiner Agneta Siegbahn Tim D. Spector Kári Stefansson David P. Strachan Bamidele O. Tayo Elena Tremoli Jaakko Tuomilehto Matti Uusitupa Cornelia M. van Duijn Péter Vollenweider Lars Wallentin Nicholas J. Wareham John B. Whitfield Bruce H. R. Wolffenbuttel José M. Ordovás Eric Boerwinkle Colin N. A. Palmer Unnur Þorsteinsdóttir Daniel I. Chasman Jerome I. Rotter Paul W. Franks Samuli Ripatti L. Adrienne Cupples Manjinder S. Sandhu Stephen S. Rich Michael Boehnke Panos Deloukas Sekar Kathiresan Karen L. Mohlke Erik Ingelsson Gonçalo R. Abecasis published in 2013. It has an Open Access status of “green”. You can read and download a PDF Full Text of this paper here.