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DOI: 10.1038/ng.2694
¤ OpenAccess: Green
This work has “Green” OA status. This means it may cost money to access on the publisher landing page, but there is a free copy in an OA repository.
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization
Klaus Bønnelykke,Melanie C. Matheson,Tune H. Pers,Raquel Granell,David P. Strachan,Alexessander Couto Alves,Allan Linneberg,John A. Curtin,Nicole M. Warrington,Marie Standl,Marjan Kerkhof,Ingileif Jónsdóttir,Blaženka Kljaić Bukvić,Marika Kaakinen,Patrick Sleimann,Guðmar Þorleifsson,Unnur Þorsteinsdóttir,Katharina Schramm,Svetlana Baltic,Eskil Kreiner‐Møller,Angela Simpson,Beaté St Pourcain,Lachlan Coin,Jennie Hui,E. Haydn Walters,Carla M. T. Tiesler,David L. Duffy,Graham Jones,Susan M. Ring,Wendy L. McArdle,Loren Price,Colin F. Robertson,Juha Pekkanen,Clara S. Tang,Elisabeth Thiering,Grant W. Montgomery,Anna-Liisa Hartikainen,Shyamali C. Dharmage,Lise Lotte Nystrup Husemoen,Christian Herder,John P. Kemp,Paul Elliot,Alan James,Mélanie Waldenberger,Michael J. Abramson,Benjamin P. Fairfax,Julian C. Knight,Ramneek Gupta,Philip J. Thompson,Patrick G. Holt,Peter D. Sly,Joel N. Hirschhorn,Mario Blekić,Stephan Weidinger,Hakon Hakonarsson,Kāri Stefánsson,Joachim Heinrich,Dirkje S. Postma,Adnan Čustović,Craig E. Pennell,Marjo‐Riitta Järvelin,Gerard H. Koppelman,Nicholas J. Timpson,Manuel Ferreira,Hans Bisgaard,John Henderson
Biology
Genome-wide association study
Genetics
2013
Allergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. We performed the first large-scale genome-wide association study (GWAS) of allergic sensitization in 5,789 affected individuals and 10,056 controls and followed up the top SNP at each of 26 loci in 6,114 affected individuals and 9,920 controls. We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from three to ten, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B. All the top SNPs were associated with allergic symptoms in an independent study. Risk-associated variants at these ten loci were estimated to account for at least 25% of allergic sensitization and allergic rhinitis. Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease.
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“Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization” is a paper by Klaus Bønnelykke Melanie C. Matheson Tune H. Pers Raquel Granell David P. Strachan Alexessander Couto Alves Allan Linneberg John A. Curtin Nicole M. Warrington Marie Standl Marjan Kerkhof Ingileif Jónsdóttir Blaženka Kljaić Bukvić Marika Kaakinen Patrick Sleimann Guðmar Þorleifsson Unnur Þorsteinsdóttir Katharina Schramm Svetlana Baltic Eskil Kreiner‐Møller Angela Simpson Beaté St Pourcain Lachlan Coin Jennie Hui E. Haydn Walters Carla M. T. Tiesler David L. Duffy Graham Jones Susan M. Ring Wendy L. McArdle Loren Price Colin F. Robertson Juha Pekkanen Clara S. Tang Elisabeth Thiering Grant W. Montgomery Anna-Liisa Hartikainen Shyamali C. Dharmage Lise Lotte Nystrup Husemoen Christian Herder John P. Kemp Paul Elliot Alan James Mélanie Waldenberger Michael J. Abramson Benjamin P. Fairfax Julian C. Knight Ramneek Gupta Philip J. Thompson Patrick G. Holt Peter D. Sly Joel N. Hirschhorn Mario Blekić Stephan Weidinger Hakon Hakonarsson Kāri Stefánsson Joachim Heinrich Dirkje S. Postma Adnan Čustović Craig E. Pennell Marjo‐Riitta Järvelin Gerard H. Koppelman Nicholas J. Timpson Manuel Ferreira Hans Bisgaard John Henderson published in 2013. It has an Open Access status of “green”. You can read and download a PDF Full Text of this paper here.