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DOI: 10.1038/ng.2390
¤ OpenAccess: Green
This work has “Green” OA status. This means it may cost money to access on the publisher landing page, but there is a free copy in an OA repository.
Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma
Eranga N. Vithana,Chiea Chuen Khor,Chunyan Qiao,Monisha E. Nongpiur,Ronnie George,Lijia Chen,Tan D,Khaled K. Abu-Amero,Chor Kai Huang,Sancy Low,Ahmad Tajudin Liza-Sharmini,Shamira A. Perera,Ching‐Yu Cheng,Liang Xu,Jia Huang,Ching-Lin Ho,Kar Seng Sim,Renyi Wu,Clement C. Tham,Paul Chew,Daniel Su,Francis T.S. Oen,Sarangapani Sripriya,Nagaswamy Soumittra,Essam Osman,Hon-Tym Wong,Guangxian Tang,Sujie Fan,Hua Meng,Dao Tl Huong,Hua Wang,Bo Feng,Mani Baskaran,Shantha Balekudaru,Vedam Lakshmi Ramprasad,Govindasamy Kumaramanickavel,Sudha K. Iyengar,Alicia C. How,Kelvin Y. Lee,Theru A. Sivakumaran,Victor H. K. Yong,Serena M. L. Ting,Yang Li,Yaxing Wang,Wan-Ting Tay,Xueling Sim,Raghavan Lavanya,Belinda K. Cornes,Yingfeng Zheng,Tina Wong,Seng-Chee Loon,Vernon K. Yong,Naushin Waseem,Azhany Yaakub,Chia Ks,R. Rand Allingham,Michael A. Hauser,Dennis S.C. Lam,Martin L. Hibberd,Siladitya Bhattacharya,Mingzhi Zhang,Yik Ying Teo,Donald Tan,Jost B. Jonas,E. Shyong Tai,Seang‐Mei Saw,Nhu Hon,Saleh A. Al-Obeidan,Jianjun Li,Nguyen Bich Chau Tran,Cameron P. Simmons,Jin‐Xin Bei,Yi-Xin Zeng,Paul J. Foster,Lingam Vijaya,Tien‐Yin Wong,Chi‐Pui Pang,Ke Wang,Tin Aung
Biology
Genetics
Glaucoma
2012
Ningli Wang, Tin Aung and colleagues report genome-wide association analyses for primary angle closure glaucoma, a major cause of blindness worldwide. They identify three loci newly associated with this disease. Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study including 1,854 PACG cases and 9,608 controls across 5 sample collections in Asia. Replication experiments were conducted in 1,917 PACG cases and 8,943 controls collected from a further 6 sample collections. We report significant associations at three new loci: rs11024102 in PLEKHA7 (per-allele odds ratio (OR) = 1.22; P = 5.33 × 10−12), rs3753841 in COL11A1 (per-allele OR = 1.20; P = 9.22 × 10−10) and rs1015213 located between PCMTD1 and ST18 on chromosome 8q (per-allele OR = 1.50; P = 3.29 × 10−9). Our findings, accumulated across these independent worldwide collections, suggest possible mechanisms explaining the pathogenesis of PACG.
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“Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma” is a paper by Eranga N. Vithana Chiea Chuen Khor Chunyan Qiao Monisha E. Nongpiur Ronnie George Lijia Chen Tan D Khaled K. Abu-Amero Chor Kai Huang Sancy Low Ahmad Tajudin Liza-Sharmini Shamira A. Perera Ching‐Yu Cheng Liang Xu Jia Huang Ching-Lin Ho Kar Seng Sim Renyi Wu Clement C. Tham Paul Chew Daniel Su Francis T.S. Oen Sarangapani Sripriya Nagaswamy Soumittra Essam Osman Hon-Tym Wong Guangxian Tang Sujie Fan Hua Meng Dao Tl Huong Hua Wang Bo Feng Mani Baskaran Shantha Balekudaru Vedam Lakshmi Ramprasad Govindasamy Kumaramanickavel Sudha K. Iyengar Alicia C. How Kelvin Y. Lee Theru A. Sivakumaran Victor H. K. Yong Serena M. L. Ting Yang Li Yaxing Wang Wan-Ting Tay Xueling Sim Raghavan Lavanya Belinda K. Cornes Yingfeng Zheng Tina Wong Seng-Chee Loon Vernon K. Yong Naushin Waseem Azhany Yaakub Chia Ks R. Rand Allingham Michael A. Hauser Dennis S.C. Lam Martin L. Hibberd Siladitya Bhattacharya Mingzhi Zhang Yik Ying Teo Donald Tan Jost B. Jonas E. Shyong Tai Seang‐Mei Saw Nhu Hon Saleh A. Al-Obeidan Jianjun Li Nguyen Bich Chau Tran Cameron P. Simmons Jin‐Xin Bei Yi-Xin Zeng Paul J. Foster Lingam Vijaya Tien‐Yin Wong Chi‐Pui Pang Ke Wang Tin Aung published in 2012. It has an Open Access status of “green”. You can read and download a PDF Full Text of this paper here.