ϟ
DOI: 10.1038/ng.214
¤ OpenAccess: Green
This work has “Green” OA status. This means it may cost money to access on the publisher landing page, but there is a free copy in an OA repository.
Evidence for two independent prostate cancer risk–associated loci in the HNF1B gene at 17q12
Jielin Sun,S. Lilly Zheng,Fredrik Wiklund,Sarah D. Isaacs,Lina D. Purcell,Zhengrong Gao,Fang Chi Hsu,Seong-Tae Kim,Wennuan Liu,Yi Zhu,Pär Stattin,Hans Olov Adami,Kathleen E. Wiley,Latchezar Dimitrov,Jing Sun,Tao Li,Aubrey R. Turner,Tamara S. Adams,Jan Adolfsson,Jan Johansson,James Lowey,Bruce J. Trock,Alan W. Partin,Patrick C. Walsh,Jeffrey M. Trent,David Duggan,John D. Carpten,Bao Li Chang,Henrik Grönberg,William B. Isaacs,Jianfeng Xu
Locus (genetics)
HNF1B
Biology
2008
William Isaacs and colleagues report evidence for a second prostate cancer risk locus in the HNF1B gene at 17q12, ∼26 kb from the previously reported risk locus in this region. The two loci are separated by a recombination hot spot and contribute independently to prostate cancer risk. We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, ∼26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 × 10−9 for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP.
Loading...
- MLA
- APA
- Chicago
- IEEE
- Harvard
- BibTeX
Cite this:
Generate Citation
“Evidence for two independent prostate cancer risk–associated loci in the HNF1B gene at 17q12” is a paper by Jielin Sun S. Lilly Zheng Fredrik Wiklund Sarah D. Isaacs Lina D. Purcell Zhengrong Gao Fang Chi Hsu Seong-Tae Kim Wennuan Liu Yi Zhu Pär Stattin Hans Olov Adami Kathleen E. Wiley Latchezar Dimitrov Jing Sun Tao Li Aubrey R. Turner Tamara S. Adams Jan Adolfsson Jan Johansson James Lowey Bruce J. Trock Alan W. Partin Patrick C. Walsh Jeffrey M. Trent David Duggan John D. Carpten Bao Li Chang Henrik Grönberg William B. Isaacs Jianfeng Xu published in 2008. It has an Open Access status of “green”. You can read and download a PDF Full Text of this paper here.