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DOI: 10.1038/ng.120
¤ OpenAccess: Green
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Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Eleftheria Zeggini,Laura J. Scott,Richa Saxena,Benjamin F. Voight,Jonathan Marchini,Tianle Hu,de Bakker Piw.,Gonçalo R. Abecasis,Peter Almgren,Gitte Andersen,Kristin Ardlie,Kristina Bengtsson Boström,Richard N. Bergman,Lori L. Bonnycastle,Knut Borch‐Johnsen,Noël P. Burtt,H Chen,Peter S. Chines,Mark J. Daly,Parimal Deodhar,Ding C-J.,Alex S.F. Doney,William L. Duren,Katherine S. Elliott,Michael R. Erdos,Timothy M. Frayling,Rachel M. Freathy,Lauren Gianniny,Harald Grallert,Niels Grarup,Christopher J. Groves,Candace Guiducci,Torben Hansen,Christian Herder,G. A. Hitman,Thomas E. Hughes,Bo Isomaa,Anne Jackson,Torben Jørgensen,Augustine Kong,Kari Kubalanza,Finny G. Kuruvilla,Johanna Kuusisto,Claudia Langenberg,Hana Lango,Torsten Lauritzen,Y Li,Cecilia M. Lindgren,Valeriya Lyssenko,Amanda F. Marvelle,Christa Meisinger,Kristian Midthjell,Karen L. Mohlke,Mario A. Morken,Andrew D. Morris,N Narisu,Peter M. Nilsson,Katharine R. Owen,Colin N.A. Palmer,Felicity Payne,Perry Jrb.,Elin Pettersen,Carl P. Platou,Inga Prokopenko,Lü Qi,Qin Li,Nigel W. Rayner,Matthew G. Rees,Jeffrey J. Roix,Annelli Sandbæk,Beverley M. Shields,Marketa Sjögren,Valgerður Steinthórsdóttir,Heather M. Stringham,Amy J. Swift,Guðmar Þorleifsson,U Thorsteinsdottir,Nicholas J. Timpson,Tiinamaija Tuomi,Mark Walker,Richard M. Watanabe,Michael N. Weedon,Cristen J. Willer,Thomas Illig,Kristian Hveem,Frank B. Hu,Markku Laakso,Kāri Stefánsson,Oluf Pedersen,Nicholas J. Wareham,Inês Barroso,Andrew T. Hattersley,Francis S. Collins,Leif Groop,Mark McCarthy,Michael Boehnke,David Altshuler
Genome-wide association study
Biology
Genetics
2008
Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly but reproducibly influence risk of type 2 diabetes (T2D). Established associations to common and rare variants explain only a small proportion of the heritability of T2D. As previously published analyses had limited power to identify variants with modest effects, we carried out meta-analysis of three T2D GWA scans comprising 10,128 individuals of European descent and approximately 2.2 million SNPs (directly genotyped and imputed), followed by replication testing in an independent sample with an effective sample size of up to 53,975. We detected at least six previously unknown loci with robust evidence for association, including the JAZF1 (P = 5.0 x 10(-14)), CDC123-CAMK1D (P = 1.2 x 10(-10)), TSPAN8-LGR5 (P = 1.1 x 10(-9)), THADA (P = 1.1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D.
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“Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes” is a paper by Eleftheria Zeggini Laura J. Scott Richa Saxena Benjamin F. Voight Jonathan Marchini Tianle Hu de Bakker Piw. Gonçalo R. Abecasis Peter Almgren Gitte Andersen Kristin Ardlie Kristina Bengtsson Boström Richard N. Bergman Lori L. Bonnycastle Knut Borch‐Johnsen Noël P. Burtt H Chen Peter S. Chines Mark J. Daly Parimal Deodhar Ding C-J. Alex S.F. Doney William L. Duren Katherine S. Elliott Michael R. Erdos Timothy M. Frayling Rachel M. Freathy Lauren Gianniny Harald Grallert Niels Grarup Christopher J. Groves Candace Guiducci Torben Hansen Christian Herder G. A. Hitman Thomas E. Hughes Bo Isomaa Anne Jackson Torben Jørgensen Augustine Kong Kari Kubalanza Finny G. Kuruvilla Johanna Kuusisto Claudia Langenberg Hana Lango Torsten Lauritzen Y Li Cecilia M. Lindgren Valeriya Lyssenko Amanda F. Marvelle Christa Meisinger Kristian Midthjell Karen L. Mohlke Mario A. Morken Andrew D. Morris N Narisu Peter M. Nilsson Katharine R. Owen Colin N.A. Palmer Felicity Payne Perry Jrb. Elin Pettersen Carl P. Platou Inga Prokopenko Lü Qi Qin Li Nigel W. Rayner Matthew G. Rees Jeffrey J. Roix Annelli Sandbæk Beverley M. Shields Marketa Sjögren Valgerður Steinthórsdóttir Heather M. Stringham Amy J. Swift Guðmar Þorleifsson U Thorsteinsdottir Nicholas J. Timpson Tiinamaija Tuomi Mark Walker Richard M. Watanabe Michael N. Weedon Cristen J. Willer Thomas Illig Kristian Hveem Frank B. Hu Markku Laakso Kāri Stefánsson Oluf Pedersen Nicholas J. Wareham Inês Barroso Andrew T. Hattersley Francis S. Collins Leif Groop Mark McCarthy Michael Boehnke David Altshuler published in 2008. It has an Open Access status of “green”. You can read and download a PDF Full Text of this paper here.