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A genome-wide association study of marginal zone lymphoma shows association to the HLA region

Joseph Vijai,Zhaoming Wang,Sonja I. Berndt,Christine F. Skibola,Susan L. Slager,Sílvia de Sanjosé,Mads Melbye,Bengt Glimelius,Paige M. Bracci,Lucía Conde,Brenda M. Birmann,Sophia Wang,Angela Brooks‐Wilson,Qing Lan,Paul I. W. de Bakker,Roel Vermeulen,Carol S. Portlock,Stephen M. Ansell,Brian K. Link,Jacques Riby,Kari E. North,Jian Gu,Henrik Hjalgrim,Wendy Cozen,Nikolaus Becker,Lauren R. Teras,John J. Spinelli,Jennifer Turner,Yawei Zhang,Mark P. Purdue,Graham G. Giles,Rachel S. Kelly,Anne Zeleniuch‐Jacquotte,Maria Grazia Ennas,A. Monnereau,Kimberly A. Bertrand,Demetrius Albanês,Tracy Lightfoot,Meredith Yeager,Charles C. Chung,Laurie Burdett,Amy Hutchinson,Charles E. Lawrence,Rebecca Montalvan,Liming Liang,Jinyan Huang,Baoshan Ma,Danylo Villano,Ann Maria,Marina Corines,Tinu Thomas,Anne J. Novak,Ahmet Doğan,Mark Liebow,Carrie A. Thompson,Thomas E. Witzig,Thomas M. Habermann,George J. Weiner,Martyn T. Smith,Elizabeth A. Holly,Rebecca D. Jackson,Lesley F. Tinker,Yuanqing Ye,Hans‐Olov Adami,Karin E. Smedby,Anneclaire J. De Roos,Patricia Hartge,Lindsay M. Morton,Richard K. Severson,Yolanda Benavente,Paolo Boffetta,Paul Brennan,Lenka Foretová,Marc Maynadié,James D. McKay,Anthony Staines,W. Ryan Diver,Claire M. Vajdic,Bruce K. Armstrong,Anne Kricker,Tongzhang Zheng,Theodore R. Holford,Gianluca Severi,Paolo Víneis,Giovanni Maria Ferri,R Ricco,Lucia Miligi,Jacqueline Clavel,Edward Giovannucci,Peter Kraft,Jarmo Virtamo,Alex Smith,Eleanor Kane,Eve Roman,Brian C.‐H. Chiu,Joseph F. Fraumeni,Xifeng Wu,James R. Cerhan,Kenneth Offit,Stephen J. Chanock,Nathaniel Rothman,Alexandra Nieters

Genome-wide association study

Lymphoma

Human leukocyte antigen

2015

Abstract Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P =3.95 × 10 −15 ) and HLA-B (rs2922994, P =2.43 × 10 −9 ) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.

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“A genome-wide association study of marginal zone lymphoma shows association to the HLA region” is a paper by Joseph Vijai Zhaoming Wang Sonja I. Berndt Christine F. Skibola Susan L. Slager Sílvia de Sanjosé Mads Melbye Bengt Glimelius Paige M. Bracci Lucía Conde Brenda M. Birmann Sophia Wang Angela Brooks‐Wilson Qing Lan Paul I. W. de Bakker Roel Vermeulen Carol S. Portlock Stephen M. Ansell Brian K. Link Jacques Riby Kari E. North Jian Gu Henrik Hjalgrim Wendy Cozen Nikolaus Becker Lauren R. Teras John J. Spinelli Jennifer Turner Yawei Zhang Mark P. Purdue Graham G. Giles Rachel S. Kelly Anne Zeleniuch‐Jacquotte Maria Grazia Ennas A. Monnereau Kimberly A. Bertrand Demetrius Albanês Tracy Lightfoot Meredith Yeager Charles C. Chung Laurie Burdett Amy Hutchinson Charles E. Lawrence Rebecca Montalvan Liming Liang Jinyan Huang Baoshan Ma Danylo Villano Ann Maria Marina Corines Tinu Thomas Anne J. Novak Ahmet Doğan Mark Liebow Carrie A. Thompson Thomas E. Witzig Thomas M. Habermann George J. Weiner Martyn T. Smith Elizabeth A. Holly Rebecca D. Jackson Lesley F. Tinker Yuanqing Ye Hans‐Olov Adami Karin E. Smedby Anneclaire J. De Roos Patricia Hartge Lindsay M. Morton Richard K. Severson Yolanda Benavente Paolo Boffetta Paul Brennan Lenka Foretová Marc Maynadié James D. McKay Anthony Staines W. Ryan Diver Claire M. Vajdic Bruce K. Armstrong Anne Kricker Tongzhang Zheng Theodore R. Holford Gianluca Severi Paolo Víneis Giovanni Maria Ferri R Ricco Lucia Miligi Jacqueline Clavel Edward Giovannucci Peter Kraft Jarmo Virtamo Alex Smith Eleanor Kane Eve Roman Brian C.‐H. Chiu Joseph F. Fraumeni Xifeng Wu James R. Cerhan Kenneth Offit Stephen J. Chanock Nathaniel Rothman Alexandra Nieters published in 2015. It has an Open Access status of “gold”. You can read and download a PDF Full Text of this paper here.