DOI: 10.1038/ncomms3151

¤ OpenAccess: Bronze

This work has “Bronze” OA status. This means it is free to read on the publisher landing page, but without any identifiable license.

Metagenome-wide analysis of antibiotic resistance genes in a large cohort of human gut microbiota

Yongfei Hu,Xi Yang,Junjie Qin,Na Lü,Chen Gong,Na Wu,Yuanlong Pan,Jing Li,Liying Zhu,Xin Wang,Zhiqi Meng,Fangqing Zhao,Di Liu,Juncai Ma,Nan Qin,Charlie Xiang,Yonghong Xiao,Lanjuan Li,Huanming Yang,Jian Wang,Ruifu Yang,George F. Gao,Jun Wang,Baoli Zhu

Metagenomics

Antibiotic resistance

Gene

2013

The human gut microbiota is a reservoir of antibiotic resistance genes, but little is known about their diversity and richness within the gut. Here we analyse the antibiotic resistance genes of gut microbiota from 162 individuals. We identify a total of 1,093 antibiotic resistance genes and find that Chinese individuals harbour the highest number and abundance of antibiotic resistance genes, followed by Danish and Spanish individuals. Single-nucleotide polymorphism-based analysis indicates that antibiotic resistance genes from the two European populations are more closely related while the Chinese ones are clustered separately. We also confirm high abundance of tetracycline resistance genes with this large cohort study. Our study provides a broad view of antibiotic resistance genes in the human gut microbiota.

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“Metagenome-wide analysis of antibiotic resistance genes in a large cohort of human gut microbiota” is a paper by Yongfei Hu Xi Yang Junjie Qin Na Lü Chen Gong Na Wu Yuanlong Pan Jing Li Liying Zhu Xin Wang Zhiqi Meng Fangqing Zhao Di Liu Juncai Ma Nan Qin Charlie Xiang Yonghong Xiao Lanjuan Li Huanming Yang Jian Wang Ruifu Yang George F. Gao Jun Wang Baoli Zhu published in 2013. It has an Open Access status of “bronze”. You can read and download a PDF Full Text of this paper here.