DOI: 10.1038/nature13302

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A draft map of the human proteome

Min‐Sik Kim,Sneha M. Pinto,Derese Getnet,Raja Sekhar Nirujogi,Srikanth S. Manda,Raghothama Chaerkady,Anil K. Madugundu,Dhanashree Kelkar,Ruth Isserlin,Shobhit Jain,Joji Kurian Thomas,Babylakshmi Muthusamy,Pamela Leal-Rojas,Praveen Kumar,Nandini A. Sahasrabuddhe,Lavanya Balakrishnan,Jayshree Advani,B George,Santosh Renuse,Lakshmi Dhevi N. Selvan,Arun H. Patil,Vishalakshi Nanjappa,Aneesha Radhakrishnan,Samarjeet Prasad,Tejaswini Subbannayya,Rajesh Raju,Manish Kumar,Sreelakshmi K. Sreenivasamurthy,Arivusudar Marimuthu,Gajanan Sathe,Sandip Chavan,Keshava K. Datta,Yashwanth Subbannayya,Apeksha Sahu,Soujanya D. Yelamanchi,Savita Jayaram,Padmavathy Rajagopalan,Jyoti Sharma,Krishna R Murthy,Nazia Syed,Renu Goel,Aafaque Ahmad Khan,Sartaj Ahmad,Gourav Dey,Keshav Mudgal,Aditi Chatterjee,Tai‐Chung Huang,Jun Zhong,Xinyan Wu,Patrick G. Shaw,Donald Freed,Muhammad Saddiq Zahari,Kanchan Kumar Mukherjee,Subramanian Shankar,Anita Mahadevan,Henry Lam,Christopher J. Mitchell,Susarla Krishna Shankar,Parthasarathy Satishchandra,John T. Schroeder,Ravi Sirdeshmukh,Anirban Maitra,Steven D. Leach,Charles G. Drake,Marc K. Halushka,T. S. Keshava Prasad,Ralph H. Hruban,Candace L. Kerr,Gary D. Bader,Christine A. Iacobuzio‐Donahue,Harsha Gowda,Akhilesh Pandey

Human proteome project

Proteome

Pseudogene

2014

The availability of human genome sequence has transformed biomedical research over the past decade. However, an equivalent map for the human proteome with direct measurements of proteins and peptides does not exist yet. Here we present a draft map of the human proteome using high-resolution Fourier-transform mass spectrometry. In-depth proteomic profiling of 30 histologically normal human samples, including 17 adult tissues, 7 fetal tissues and 6 purified primary haematopoietic cells, resulted in identification of proteins encoded by 17,294 genes accounting for approximately 84% of the total annotated protein-coding genes in humans. A unique and comprehensive strategy for proteogenomic analysis enabled us to discover a number of novel protein-coding regions, which includes translated pseudogenes, non-coding RNAs and upstream open reading frames. This large human proteome catalogue (available as an interactive web-based resource at http://www.humanproteomemap.org) will complement available human genome and transcriptome data to accelerate biomedical research in health and disease.

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“A draft map of the human proteome” is a paper by Min‐Sik Kim Sneha M. Pinto Derese Getnet Raja Sekhar Nirujogi Srikanth S. Manda Raghothama Chaerkady Anil K. Madugundu Dhanashree Kelkar Ruth Isserlin Shobhit Jain Joji Kurian Thomas Babylakshmi Muthusamy Pamela Leal-Rojas Praveen Kumar Nandini A. Sahasrabuddhe Lavanya Balakrishnan Jayshree Advani B George Santosh Renuse Lakshmi Dhevi N. Selvan Arun H. Patil Vishalakshi Nanjappa Aneesha Radhakrishnan Samarjeet Prasad Tejaswini Subbannayya Rajesh Raju Manish Kumar Sreelakshmi K. Sreenivasamurthy Arivusudar Marimuthu Gajanan Sathe Sandip Chavan Keshava K. Datta Yashwanth Subbannayya Apeksha Sahu Soujanya D. Yelamanchi Savita Jayaram Padmavathy Rajagopalan Jyoti Sharma Krishna R Murthy Nazia Syed Renu Goel Aafaque Ahmad Khan Sartaj Ahmad Gourav Dey Keshav Mudgal Aditi Chatterjee Tai‐Chung Huang Jun Zhong Xinyan Wu Patrick G. Shaw Donald Freed Muhammad Saddiq Zahari Kanchan Kumar Mukherjee Subramanian Shankar Anita Mahadevan Henry Lam Christopher J. Mitchell Susarla Krishna Shankar Parthasarathy Satishchandra John T. Schroeder Ravi Sirdeshmukh Anirban Maitra Steven D. Leach Charles G. Drake Marc K. Halushka T. S. Keshava Prasad Ralph H. Hruban Candace L. Kerr Gary D. Bader Christine A. Iacobuzio‐Donahue Harsha Gowda Akhilesh Pandey published in 2014. It has an Open Access status of “green”. You can read and download a PDF Full Text of this paper here.