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DOI: 10.1038/nature10166
¤ OpenAccess: Bronze
This work has “Bronze” OA status. This means it is free to read on the publisher landing page, but without any identifiable license.
Integrated genomic analyses of ovarian carcinoma
Debra A. Bell,Andrew Berchuck,Michael J. Birrer,Jeremy Chien,Daniel W. Cramer,Fanny Dao,Rajiv Dhir,Philip J. DiSaia,Hani Gabra,Pat Glenn,Andrew K. Godwin,Jenny Gross,Lynn C. Hartmann,Meizhen Huang,David G. Huntsman,Mary Iacocca,Marcin Imieliński,Steve E. Kalloger,Beth Y. Karlan,Douglas A. Levine,Gordon B. Mills,Carl Morrison,David G. Mutch,Narciso Olvera,Sandra Oršulić,K. Park,Nicholas J. Petrelli,Brenda Rabeno,Janet S. Rader,Branimir I. Šikić,Karen Smith‐McCune,Anil K. Sood,David D.L. Bowtell,Robert Penny,Joseph R. Testa,Kyle Chang,Huyen Dinh,Jennifer Drummond,Gerald R. Fowler,Preethi H. Gunaratne,Alicia Hawes,Christie Kovar,Lora Lewis,Margaret Morgan,Irene Newsham,Jireh Santibanez,Jeffrey G. Reid,Lisa R. Treviño,Ye Wu,M. Wang,Donna M. Muzny,David A. Wheeler,Richard A. Gibbs,Gad Getz,Michael S. Lawrence,Kristian Cibulskis,Andrey Sivachenko,Carrie Sougnez,Doug Voet,Jane Wilkinson,Toby Bloom,Kristin Ardlie,Tim Fennell,Jennifer Baldwin,Stacey Gabriel,Eric S. Lander,Ding Li,Robert S. Fulton,Daniel C. Koboldt,Michael D. McLellan,Todd Wylie,Joan Walker,Michelle D. O’Laughlin,David J. Dooling,Lucinda A. Fulton,Rachel M. Abbott,Nathan D. Dees,Q. Zhang,Cyriac Kandoth,Michael C. Wendl,William Schierding,Dong Shen,Christopher Harris,Heather Schmidt,Joelle Kalicki,Kim D. Delehaunty,Catrina C. Fronick,Ryan Demeter,Linda S. Cook,John W. Wallis,Liang In Lin,Vincent Magrini,James S. Hodges,James M. Eldred,S. M. Smith,Craig Pohl,Fabio Vandin,Benjamin J. Raphael,George M. Weinstock,Elaine R. Mardis,Richard K. Wilson,Matthew Meyerson,Wendy Winckler,Roeland Verhaak,S. L. Carter,Craig H. Mermel,Gordon Saksena,Huy Nguyen,Robert C. Onofrio,Diana Hubbard,Sumeet Gupta,Andrew Crenshaw,Alex H. Ramos,Lynda Chin,Alexei Protopopov,Jinghui Zhang,T. M. Kim,Ilana Perna,Yuanyuan Xiao,H. Zhang,Gang Ren,N. Sathiamoorthy,R. W. Park,E. Lee,P. J. Park,Raju Kucherlapati,Devin Absher,Lindsay L. Waite,Gavin Sherlock,Julia Brooks,J. Z. Li,Jishu Xu,Rae Myers,Peter W. Laird,Leslie Cope,James G. Herman,Hui Shen,Daniel J. Weisenberger,Houtan Noushmehr,Fei Pan,Tim Triche,Benjamin P. Berman,David J. Van Den Berg,Jermya Buckley,Stephen B. Baylin,Paul T. Spellman,Elizabeth Purdom,Pierre Neuvial,Henrik Bengtsson,Lakshmi R. Jakkula,Steffen Durinck,Jing–Dong Jackie Han,Shannon Dorton,Helen Marr,Y. G. Choi,V. Wang,N. J. Wang,John Ngai,John G. Conboy,Bahram Parvin,Heidi S. Feiler,T. P. Speed,Joe W. Gray,Nicholas D. Socci,Yupu Liang,Barry S. Taylor,Nikolaus Schultz,Laetitia Borsu,Alex E. Lash,Cameron Brennan,Agnès Viale,Chris Sander,Marc Ladanyi,Katherine A. Hoadley,Shaowu Meng,Ying Du,Yan Shi,L. Li,Yidi J. Turman,Dae Young Zang,E. B. Helms,Saianand Balu,Xianrong Zhou,Jianrong Wu,Michael D. Topal,D. Neil Hayes,Charles M. Perou,Chang Jiun Wu,Sachet A. Shukla,Andrey Sivachenko,Rui Jiang,Y. Liu,Michael S. Noble,H. Carter,D. Kim,Rachel Karchin,James E. Korkola,Laura M. Heiser,R. J. Cho,Zhiyuan Hu,Ethan Cerami,Adam B. Olshen,Boris Reva,Yevgeniy Antipin,Ronglai Shen,Parminder K. Mankoo,Robert P. Sheridan,Giovanni Ciriello,Wan Chang,Joel Bernanke,David Haussler,Christopher C. Benz,Joshua M. Stuart,Stephen C. Benz,J. Zachary Sanborn,Charles Vaske,Junyou Zhu,Christopher Szeto,Gary K. Scott,Christina Yau,Matthew D. Wilkerson,Nathan Zhang,Rehan Akbani,Keith Baggerly,W. K. Alfred Yung,John N. Weinstein,Troy Shelton,Donata Grimm,Martha Hatfield,Scott Morris,Peggy Yena,Paul Rhodes,Mark E. Sherman,Joseph Paulauskis,Sherri Z. Millis,A Kahn,J. M. Greene,Robert Sfeir,Mark A. Jensen,J. Chen,Jon Whitmore,Shelley Alonso,J. Jordan,Anna L. Chu,Anna K. Barker,Chris Compton,Greg Eley,Martin L. Ferguson,Peter Fielding,Daniela S. Gerhard,Rachel C. Myles,Carl F. Schaefer,Kenna Shaw,Jim Vaught,Jerry Vockley,Peter J. Good,Mark S. Guyer,Brad Ozenberger,Jane Peterson,Elizabeth J. Thomson
Ovarian cancer
Biology
microRNA
2011
A catalogue of molecular aberrations that cause ovarian cancer is critical for developing and deploying therapies that will improve patients' lives. The Cancer Genome Atlas project has analysed messenger RNA expression, microRNA expression, promoter methylation and DNA copy number in 489 high-grade serous ovarian adenocarcinomas and the DNA sequences of exons from coding genes in 316 of these tumours. Here we report that high-grade serous ovarian cancer is characterized by TP53 mutations in almost all tumours (96%); low prevalence but statistically recurrent somatic mutations in nine further genes including NF1, BRCA1, BRCA2, RB1 and CDK12; 113 significant focal DNA copy number aberrations; and promoter methylation events involving 168 genes. Analyses delineated four ovarian cancer transcriptional subtypes, three microRNA subtypes, four promoter methylation subtypes and a transcriptional signature associated with survival duration, and shed new light on the impact that tumours with BRCA1/2 (BRCA1 or BRCA2) and CCNE1 aberrations have on survival. Pathway analyses suggested that homologous recombination is defective in about half of the tumours analysed, and that NOTCH and FOXM1 signalling are involved in serous ovarian cancer pathophysiology.
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“Integrated genomic analyses of ovarian carcinoma” is a paper by Debra A. Bell Andrew Berchuck Michael J. Birrer Jeremy Chien Daniel W. Cramer Fanny Dao Rajiv Dhir Philip J. DiSaia Hani Gabra Pat Glenn Andrew K. Godwin Jenny Gross Lynn C. Hartmann Meizhen Huang David G. Huntsman Mary Iacocca Marcin Imieliński Steve E. Kalloger Beth Y. Karlan Douglas A. Levine Gordon B. Mills Carl Morrison David G. Mutch Narciso Olvera Sandra Oršulić K. Park Nicholas J. Petrelli Brenda Rabeno Janet S. Rader Branimir I. Šikić Karen Smith‐McCune Anil K. Sood David D.L. Bowtell Robert Penny Joseph R. Testa Kyle Chang Huyen Dinh Jennifer Drummond Gerald R. Fowler Preethi H. Gunaratne Alicia Hawes Christie Kovar Lora Lewis Margaret Morgan Irene Newsham Jireh Santibanez Jeffrey G. Reid Lisa R. Treviño Ye Wu M. Wang Donna M. Muzny David A. Wheeler Richard A. Gibbs Gad Getz Michael S. Lawrence Kristian Cibulskis Andrey Sivachenko Carrie Sougnez Doug Voet Jane Wilkinson Toby Bloom Kristin Ardlie Tim Fennell Jennifer Baldwin Stacey Gabriel Eric S. Lander Ding Li Robert S. Fulton Daniel C. Koboldt Michael D. McLellan Todd Wylie Joan Walker Michelle D. O’Laughlin David J. Dooling Lucinda A. Fulton Rachel M. Abbott Nathan D. Dees Q. Zhang Cyriac Kandoth Michael C. Wendl William Schierding Dong Shen Christopher Harris Heather Schmidt Joelle Kalicki Kim D. Delehaunty Catrina C. Fronick Ryan Demeter Linda S. Cook John W. Wallis Liang In Lin Vincent Magrini James S. Hodges James M. Eldred S. M. Smith Craig Pohl Fabio Vandin Benjamin J. Raphael George M. Weinstock Elaine R. Mardis Richard K. Wilson Matthew Meyerson Wendy Winckler Roeland Verhaak S. L. Carter Craig H. Mermel Gordon Saksena Huy Nguyen Robert C. Onofrio Diana Hubbard Sumeet Gupta Andrew Crenshaw Alex H. Ramos Lynda Chin Alexei Protopopov Jinghui Zhang T. M. Kim Ilana Perna Yuanyuan Xiao H. Zhang Gang Ren N. Sathiamoorthy R. W. Park E. Lee P. J. Park Raju Kucherlapati Devin Absher Lindsay L. Waite Gavin Sherlock Julia Brooks J. Z. Li Jishu Xu Rae Myers Peter W. Laird Leslie Cope James G. Herman Hui Shen Daniel J. Weisenberger Houtan Noushmehr Fei Pan Tim Triche Benjamin P. Berman David J. Van Den Berg Jermya Buckley Stephen B. Baylin Paul T. Spellman Elizabeth Purdom Pierre Neuvial Henrik Bengtsson Lakshmi R. Jakkula Steffen Durinck Jing–Dong Jackie Han Shannon Dorton Helen Marr Y. G. Choi V. Wang N. J. Wang John Ngai John G. Conboy Bahram Parvin Heidi S. Feiler T. P. Speed Joe W. Gray Nicholas D. Socci Yupu Liang Barry S. Taylor Nikolaus Schultz Laetitia Borsu Alex E. Lash Cameron Brennan Agnès Viale Chris Sander Marc Ladanyi Katherine A. Hoadley Shaowu Meng Ying Du Yan Shi L. Li Yidi J. Turman Dae Young Zang E. B. Helms Saianand Balu Xianrong Zhou Jianrong Wu Michael D. Topal D. Neil Hayes Charles M. Perou Chang Jiun Wu Sachet A. Shukla Andrey Sivachenko Rui Jiang Y. Liu Michael S. Noble H. Carter D. Kim Rachel Karchin James E. Korkola Laura M. Heiser R. J. Cho Zhiyuan Hu Ethan Cerami Adam B. Olshen Boris Reva Yevgeniy Antipin Ronglai Shen Parminder K. Mankoo Robert P. Sheridan Giovanni Ciriello Wan Chang Joel Bernanke David Haussler Christopher C. Benz Joshua M. Stuart Stephen C. Benz J. Zachary Sanborn Charles Vaske Junyou Zhu Christopher Szeto Gary K. Scott Christina Yau Matthew D. Wilkerson Nathan Zhang Rehan Akbani Keith Baggerly W. K. Alfred Yung John N. Weinstein Troy Shelton Donata Grimm Martha Hatfield Scott Morris Peggy Yena Paul Rhodes Mark E. Sherman Joseph Paulauskis Sherri Z. Millis A Kahn J. M. Greene Robert Sfeir Mark A. Jensen J. Chen Jon Whitmore Shelley Alonso J. Jordan Anna L. Chu Anna K. Barker Chris Compton Greg Eley Martin L. Ferguson Peter Fielding Daniela S. Gerhard Rachel C. Myles Carl F. Schaefer Kenna Shaw Jim Vaught Jerry Vockley Peter J. Good Mark S. Guyer Brad Ozenberger Jane Peterson Elizabeth J. Thomson published in 2011. It has an Open Access status of “bronze”. You can read and download a PDF Full Text of this paper here.