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DOI: 10.1038/nature08185
¤ OpenAccess: Green
This work has “Green” OA status. This means it may cost money to access on the publisher landing page, but there is a free copy in an OA repository.
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
Shaun Purcell,Naomi R. Wray,Jennifer Stone,Peter M. Visscher,Michael Conlon O'Donovan,Patrick F. Sullivan,Pamela Sklar,Douglas M. Ruderfer,Andrew McQuillin,Derek W. Morris,Colm Ó'Dúshláine,Aiden Corvin,Peter Holmans,Stuart MacGregor,Hugh Gurling,Douglas Blackwood,Nick Craddock,Michael Gill,Christina M. Hultman,George Kirov,Paul Lichtenstein,Walter Muir,Carlos N. Pato,Edward M. Scolnick,David St Clair,Nigel Williams,Lyudmila Georgieva,Ivan Nikolov,Nadine Norton,Hywel Williams,Draga Toncheva,Vihra Milanova,Emma Flordal Thelander,Patrick F. Sullivan,Elaine Kenny,Emma M. Quinn,Khalid Choudhury,Susmita Datta,Jonathan Pimm,Srinivasa Thirumalai,Vinita Puri,Robert Krasucki,Jacob Lawrence,Digby Quested,Nicholas Bass,Caroline Crombie,G. T. Fraser,Soh Leh Kuan,Nicholas Walker,Kevin A. McGhee,Ben Pickard,P. Malloy,Alan Maclean,M. Van Beck,Michele T. Pato,Helena Medeiros,Frank A. Middleton,Célia Barreto Carvalho,Christopher P. Morley,Ayman H. Fanous,David V. Conti,James A. Knowles,Carlos Paz Ferreira,A. Macedo,Maria Helena Pinto de Azevedo,Andrew Kirby,Manuel Ferreira,Mark J. Daly,Kimberly Chambert,Finny G. Kuruvilla,Stacey Gabriel,Kristin Ardlie,Jennifer L. Moran
Schizophrenia (object-oriented programming)
Bipolar disorder
Heritability
2009
Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80%. We performed a genome-wide association study of 3,322 European individuals with schizophrenia and 3,587 controls. Here we show, using two analytic approaches, the extent to which common genetic variation underlies the risk of schizophrenia. First, we implicate the major histocompatibility complex. Second, we provide molecular genetic evidence for a substantial polygenic component to the risk of schizophrenia involving thousands of common alleles of very small effect. We show that this component also contributes to the risk of bipolar disorder, but not to several non-psychiatric diseases.
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“Common polygenic variation contributes to risk of schizophrenia and bipolar disorder” is a paper by Shaun Purcell Naomi R. Wray Jennifer Stone Peter M. Visscher Michael Conlon O'Donovan Patrick F. Sullivan Pamela Sklar Douglas M. Ruderfer Andrew McQuillin Derek W. Morris Colm Ó'Dúshláine Aiden Corvin Peter Holmans Stuart MacGregor Hugh Gurling Douglas Blackwood Nick Craddock Michael Gill Christina M. Hultman George Kirov Paul Lichtenstein Walter Muir Carlos N. Pato Edward M. Scolnick David St Clair Nigel Williams Lyudmila Georgieva Ivan Nikolov Nadine Norton Hywel Williams Draga Toncheva Vihra Milanova Emma Flordal Thelander Patrick F. Sullivan Elaine Kenny Emma M. Quinn Khalid Choudhury Susmita Datta Jonathan Pimm Srinivasa Thirumalai Vinita Puri Robert Krasucki Jacob Lawrence Digby Quested Nicholas Bass Caroline Crombie G. T. Fraser Soh Leh Kuan Nicholas Walker Kevin A. McGhee Ben Pickard P. Malloy Alan Maclean M. Van Beck Michele T. Pato Helena Medeiros Frank A. Middleton Célia Barreto Carvalho Christopher P. Morley Ayman H. Fanous David V. Conti James A. Knowles Carlos Paz Ferreira A. Macedo Maria Helena Pinto de Azevedo Andrew Kirby Manuel Ferreira Mark J. Daly Kimberly Chambert Finny G. Kuruvilla Stacey Gabriel Kristin Ardlie Jennifer L. Moran published in 2009. It has an Open Access status of “green”. You can read and download a PDF Full Text of this paper here.