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Cerebral 5-HT<sub>2A</sub> Receptor and Serotonin Transporter Binding in Humans Are Not Affected by the val66met BDNF Polymorphism Status or Blood BDNF Levels

Anders Bue Klein,Viktorija Trajkovska,David Erritzøe,Steven Haugbøl,Jacob Madsen,William F.C. Baaré,Susana Aznar,Gitte M. Knudsen

Serotonin transporter

Serotonin

Internal medicine

2010

Recent studies have proposed an interrelation between the brain-derived neurotrophic factor (BDNF) val66met polymorphism and the serotonin system. In this study, we investigated whether the BDNF val66met polymorphism or blood BDNF levels are associated with cerebral 5-hydroxytryptamine 2A (5-HT(2A)) receptor or serotonin transporter (SERT) binding in healthy subjects. No statistically significant differences in 5-HT(2A) receptor or SERT binding were found between the val/val and met carriers, nor were blood BDNF values associated with SERT binding or 5-HT(2A) receptor binding. In conclusion, val66met BDNF polymorphism status is not associated with changes in the serotonergic system. Moreover, BDNF levels in blood do not correlate with either 5-HT(2A) or SERT binding.

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“Cerebral 5-HT<sub>2A</sub> Receptor and Serotonin Transporter Binding in Humans Are Not Affected by the val66met BDNF Polymorphism Status or Blood BDNF Levels” is a paper by Anders Bue Klein Viktorija Trajkovska David Erritzøe Steven Haugbøl Jacob Madsen William F.C. Baaré Susana Aznar Gitte M. Knudsen published in 2010. It has an Open Access status of “bronze”. You can read and download a PDF Full Text of this paper here.